Oncogenic drivers in 11q13 associated with prognosis and response to therapy in advanced oropharyngeal carcinomas

Objectives: To identify potential molecular drivers associated with prognosis and response to treatment in advanced oropharyngeal squamous cell carcinomas (OPSCC). Materials and methods: Thirty-three OPSCC biopsies from untreated Brazilian patients were evaluated for human papilloma virus genotyping...

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Main Authors:	Barros-Filho, M.C (Author), Carvalho, A.L (Author), Chulam, T. (Author), Drigo, S.A (Author), Hatakeyama, M. (Author), Kowalski, L.P (Author), Marchi, F.A (Author), Nicolau, U.R (Author), Pinto, C.A.L (Author), Reis-Rosa, L.A (Author), Rogatto, S.R (Author), Scapulatempo-Neto, C. (Author)
Format:	Article
Language:	English
Published:	Elsevier Ltd 2018
Subjects:	Adaptor Proteins, Signal Transducing adult algorithm Alphapapillomavirus Array comparative genomic hybridization Article Brazilian cancer patient cancer prognosis cancer radiotherapy cancer surgery carboplatin carcinogenesis Carcinoma, Squamous Cell carnitine palmitoyltransferase I carnitine palmitoyltransferase Ia cetuximab chemoradiotherapy chromosomal mapping chromosome 11 chromosome 11q chromosome 11q13 Chromosome Mapping Chromosomes, Human, Pair 11 cisplatin clinical article CONEXIC algorithm controlled study diagnostic test accuracy study docetaxel Driver alterations female Female fluorouracil gain of function mutation gene dosage gene expression profiling gene overexpression genetic database genetics genome-wide association study genomics Genomics genotype high risk patient human human cell Human papilloma virus Humans induction chemotherapy isolation and purification male Male middle aged Middle Aged multimodality cancer therapy nerve protein Nerve Tissue Proteins oncogene Oncogenes oncoprotein oraov1 protein Oropharyngeal cancer Oropharyngeal Neoplasms oropharynx squamous cell carcinoma oropharynx tumor outcome assessment papillomavirus infection ppfia1 protein PPFIA1 protein, human Predictive factors predictive value priority journal prognosis Prognosis Prognostic factors quantitative analysis receiver operating characteristic Reverse transcriptase polymerase chain reaction reverse transcription polymerase chain reaction shank2 protein SHANK2 protein, human signal transducing adaptor protein signal transduction squamous cell carcinoma transcriptome Transcriptome Transcriptome profiling treatment outcome Treatment Outcome treatment response tumor biopsy unclassified drug virology Wart virus
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Oncogenic drivers in 11q13 associated with prognosis and response to therapy in advanced oropharyngeal carcinomas

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