IκBα is required for full transcriptional induction of some NFκB-regulated genes in response to TNF in MCF-7 cells

IκBα is required for full transcriptional induction of some NFκB-regulated genes in response to TNF in MCF-7 cells

Inflammatory stimuli triggers the degradation of three inhibitory κB (IκB) proteins, allowing for nuclear translocation of nuclear factor-κB (NFκB) for transcriptional induction of its target genes. Of these three, IκBα is a well-known negative feedback regulator that limits the duration of NFκB act...

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Bibliographic Details
Main Authors: Ando, M. (Author), Hoffmann, A. (Author), Kasukawa, T. (Author), Lefaudeux, D. (Author), Magi, S. (Author), Okada, M. (Author), Seki, M. (Author), Suzuki, Y. (Author)
Format: Article
Language:English
Published: Nature Research 2021
Subjects:
gene expression regulation
Gene Expression Regulation
genetics
human
Humans
I kappa B
I kappa B kinase alpha
I-kappa B Proteins
immunoglobulin enhancer binding protein
MCF-7 cell line
MCF-7 Cells
metabolism
NF-kappa B
NF-KappaB Inhibitor alpha
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