Thymol inhibits oral squamous cell carcinoma growth via mitochondria-mediated apoptosis

Thymol inhibits oral squamous cell carcinoma growth via mitochondria-mediated apoptosis

Background: Thymol is a transient receptor potential ankyrin subtype 1 channel, (TRPA1) agonist found in thyme and oregano. Thymol has antioxidant, anti-inflammatory, and antimicrobial properties; thus, thymol is added to many commercially available products including Listerine mouthwash. Thymol is...

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Bibliographic Details
Main Authors: De La Chapa, J.J (Author), Gonzales, C.B (Author), Lee, D.R (Author), Singha, P.K (Author)
Format: Article
Language:English
Published: Blackwell Publishing Ltd 2018
Subjects:
acetylcysteine
agonists
animal
animal experiment
animal model
Animals
antineoplastic agent
Antineoplastic Agents, Phytogenic
antiproliferative activity
apoptosis
Apoptosis
Article
CAL-27 cell line
calcium
calcium transport
cancer inhibition
Carcinoma, Squamous Cell
Cell Line, Tumor
cell viability assay
clonogenic assay
controlled study
cytotoxicity
drug effect
female
HeLa cell line
HeLa Cells
histopathology
human
human cell
Humans
in vitro study
in vivo study
inflammatory infiltrate
ionomycin
listerine
membrane potential
Membrane Potential, Mitochondrial
Mice
Mitochondria
mitochondrial dysfunction
mitochondrial membrane potential
mitochondrion
mouse
mouth squamous cell carcinoma
MTS assay
n (4 isopropylphenyl) 2 (1,2,3,6 tetrahydro 1,3 dimethyl 2,6 dioxo 7h purin 7 yl)acetamide
nonhuman
oral squamous cell carcinoma
pathology
phytotherapy
Phytotherapy
priority journal
squamous cell carcinoma
study
thymol
Thymol
Tongue Neoplasms
tongue tumor
transient receptor potential channel
transient receptor potential channel A1
TRPA1
TRPA1 Cation Channel
tumor cell line
tumor volume
tumor xenograft
TUNEL assay
Western blotting
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