Identifying collateral and synthetic lethal vulnerabilities within the DNA-damage response

Identifying collateral and synthetic lethal vulnerabilities within the DNA-damage response

Background: A pair of genes is defined as synthetically lethal if defects on both cause the death of the cell but a defect in only one of the two is compatible with cell viability. Ideally, if A and B are two synthetic lethal genes, inhibiting B should kill cancer cells with a defect on A, and shoul...

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Bibliographic Details
Main Authors: Ceri, S. (Author), Pinoli, P. (Author), Srihari, S. (Author), Wong, L. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2021
Subjects:
adult
article
Biological pathways
controlled study
Copy number alteration
copy number variation
Copy number variations
Cytology
Defects
Diseases
DNA
DNA Copy Number Variations
DNA damage repair genes
DNA damage response
DNA repair
Forecasting
Genes
Genes, Lethal
Graph-based methods
Graphic methods
Highly-correlated
lethal gene
lethality
Mutation frequency
mutation rate
Mutual exclusions
prediction
Synthetic lethal
Synthetic lethality
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