The effects of leptin administration on renal function in spontaneously hypertensive rats

The effects of leptin administration on renal function in spontaneously hypertensive rats

Objective: Elevated levels of leptin may be responsible directly for progression and severity of renal disease in obesity and hypertension. It may exert its effects by promoting fibrosis through the actions of transforming growth factor-β1 (TGF-β1) and the Smad pathway. This study determines the eff...

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Bibliographic Details
Main Authors: Awang, Z. (Author), Caszo, B. (Author), Ibrahim, E. (Author), Muslim, A. (Author), Omar, E. (Author), Singh, H. (Author)
Format: Article
Language:English
Published: Innovare Academics Sciences Pvt. Ltd 2017
Subjects:
animal experiment
animal model
animal tissue
Article
controlled study
gene expression
glomerulus
Glomerulus
histopathology
hormone action
hypertension
Hypertension
kidney function
leptin
Leptin
male
messenger RNA
nonhuman
obesity
osteogenic protein 1
rat
Renal function
Smad
Smad2 protein
Spontaneously hypertensive rats
transforming growth factor beta1
Transforming growth factor-β1
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