A Leucyl‐tRNA Synthetase Urzyme: Authenticity of tRNA Synthetase Catalytic Activities and Promiscuous Phosphorylation of Leucyl‐5′AMP

A Leucyl‐tRNA Synthetase Urzyme: Authenticity of tRNA Synthetase Catalytic Activities and Promiscuous Phosphorylation of Leucyl‐5′AMP

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Aminoacyl‐tRNA synthetase (aaRS)/tRNA cognate pairs translate the genetic code by synthesizing specific aminoacyl‐tRNAs that are assembled on messenger RNA by the ribosome. Deconstruction of the two distinct aaRS superfamilies (Classes) has provided conceptual and experimental models for their early...

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Bibliographic Details
Main Authors: Carter, C.W., Jr (Author), Hobson, J.J (Author), Hu, H. (Author), Li, Z. (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
evolutionary changes in the occupation of sequence space
evolutionary intermediates
genetic coding
mechanistic enzymology
protein engineering
protein synthesis
single turnover kinetics
structural biology
validating weak catalytic activities
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