Iron Saturation Drives Lactoferrin Effects on Oxidative Stress and Neurotoxicity Induced by HIV-1 Tat

Iron Saturation Drives Lactoferrin Effects on Oxidative Stress and Neurotoxicity Induced by HIV-1 Tat

The Trans-Activator of Transcription (Tat) of Human Immunodeficiency Virus (HIV-1) is involved in virus replication and infection and can promote oxidative stress in human astroglial cells. In response, host cells activate transcription of antioxidant genes, including a subunit of System Xc− cystine...

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Bibliographic Details
Main Authors: Bonaccorsi di Patti, M.C (Author), Carpinelli, L. (Author), Casella, C. (Author), Colasanti, M. (Author), Cutone, A. (Author), D’Ezio, V. (Author), Ianiro, G. (Author), Musci, G. (Author), Persichini, T. (Author), Rosa, L. (Author), Valenti, P. (Author)
Format: Article
Language:English
Published: MDPI 2023
Subjects:
astrocytes
HIV-1 Tat
iron saturation
Lactoferrin
neurotoxicity
Nrf-2
oxidative stress
System Xc−
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