Selective toxicity of the anthelmintic emodepside revealed by heterologous expression of human KCNMA1 in caenorhabditis elegans
Emodepside is a resistance-breaking anthelmintic of a new chemical class, the cyclooctadepsipeptides. A major determinant of its anthelmintic effect is the calcium-activated potassium channel, SLO-1. SLO-1 belongs to a family of channels that are highly conserved across the animal phyla and regulate...
Main Authors: | Crisford, Anna (Author), Murray, Caitriona (Author), O'Connor, Vincent (Author), Edwards, Richard J. (Author), Kruger, Nina (Author), Welz, Claudia (Author), von Samson-Himmelstjerna, Georg (Author), Harder, Achim (Author), Walker, Robert J. (Author), Holden-Dye, Lindy (Author) |
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Format: | Article |
Language: | English |
Published: |
2011.
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Subjects: | |
Online Access: | Get fulltext |
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