Functional loss of IKBE leads to NF-KB deregulation in aggressive chronic lymphocytic leukemia

Functional loss of IKBE leads to NF-KB deregulation in aggressive chronic lymphocytic leukemia

NF-?B is constitutively activated in chronic lymphocytic leukemia (CLL); however, the implicated molecular mechanisms remain largely unknown. Thus, we performed targeted deep sequencing of 18 core complex genes within the NF-?B pathway in a discovery and validation CLL cohort totaling 315 cases. The...

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Main Authors: Mansouri, L. (Author), Sutton, L.A (Author), Ljungstrom, V. (Author), Bondza, S. (Author), Arngården, L (Author), Bhoi, S (Author), Larsson, J (Author), Cortese, D (Author), Kalushkova, A (Author), Plevova, K (Author), Young, E (Author), Gunnarsson, R (Author), Falk-Sörqvist, E (Author), Lönn, P (Author), Muggen, A (Author), Yan, XJ (Author), Sander, B (Author), Enblad, G (Author), Smedby, KE (Author), Juliusson, G (Author), Belessi, C (Author), Rung, J (Author), Chiorazzi, N (Author), Strefford, Jon (Author), Langerak, AW (Author), Pospisilova, S (Author), Davi, F (Author), Hellström, M (Author), Jernberg-Wiklund, H (Author), Ghia, P (Author), Söderberg, O (Author), Stamatopoulos, K (Author), Nilsson, M (Author), Rosenquist, R (Author)
Format: Article
Language:English
Published: 2015-06-01.
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