The class A macrophage scavenger receptor attenuates CXC chemokine production and the early infiltration of neutrophils in sterile peritonitis
The macrophage scavenger receptor (SR-A) is a multifunctional receptor that is associated with several important pathological conditions, including atherosclerosis. In this study, we show, using a sterile peritonitis model, that it can regulate the inflammatory response. SR-A null mice display an in...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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2004.
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| Subjects: | |
| Online Access: | Get fulltext |
| LEADER | 01355 am a22001453u 4500 | ||
|---|---|---|---|
| 001 | 41142 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Cotena, Alessia |e author |
| 700 | 1 | 0 | |a Gordon, Siamon |e author |
| 700 | 1 | 0 | |a Platt, Nick |e author |
| 245 | 0 | 0 | |a The class A macrophage scavenger receptor attenuates CXC chemokine production and the early infiltration of neutrophils in sterile peritonitis |
| 260 | |c 2004. | ||
| 856 | |z Get fulltext |u https://eprints.soton.ac.uk/41142/1/Cotena_et_al_pdf.pdf | ||
| 520 | |a The macrophage scavenger receptor (SR-A) is a multifunctional receptor that is associated with several important pathological conditions, including atherosclerosis. In this study, we show, using a sterile peritonitis model, that it can regulate the inflammatory response. SR-A null mice display an increased initial granulocytic infiltration because of overproduction of the CXC chemokines, MIP-2 and keratinocyte-derived cytokine. This differential response is dependent upon particle internalization and can be mimicked by advanced glycation end product-BSA-conjugated latex beads. Thus SR-A is a nonactivating receptor, which is the first example of a pattern recognition receptor that serves to counter the activities of proinflammatory receptors and attenuates the production of specific chemokines to ensure an inflammatory response of the appropriate magnitude. | ||
| 655 | 7 | |a Article | |