Mutational analysis of CYP2C8 in hypertensive patients using denaturing high performance liquid chromatography
What is known and Objective: CYP2C8 is involved in the cytochrome P450 (CYP) epoxygenase pathway. Arachidonic acid metabolites such as epoxyeicosatrienenoic acids and hydroxyeicosatetrenoic acids, produced may have a role in hypertension. We aimed to develop a medium through-put method for screening...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Series: | JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
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| Online Access: | View Fulltext in Publisher |
| Summary: | What is known and Objective: CYP2C8 is involved in the cytochrome P450 (CYP) epoxygenase pathway. Arachidonic acid metabolites such as epoxyeicosatrienenoic acids and hydroxyeicosatetrenoic acids, produced may have a role in hypertension. We aimed to develop a medium through-put method for screening samples of known and new mutations of CYP2C8 using denaturing high performance liquid chromatography (DHPLC). |
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| ISBN: | 0269-4727 1365-2710 |
| ISSN: | 1365-2710 |
| DOI: | 10.1111/j.1365-2710.2009.01146.x |