Hypoxia-Induced Neuroinflammation in Alzheimer's Disease: Potential Neuroprotective Effects of Centella asiatica

Hypoxia-Induced Neuroinflammation in Alzheimer's Disease: Potential Neuroprotective Effects of Centella asiatica

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Alzheimer's disease (AD) is a neurodegenerative disorder that is characterised by the presence of extracellular beta-amyloid fibrillary plaques and intraneuronal neurofibrillary tau tangles in the brain. Recurring failures of drug candidates targeting these pathways have prompted research in AD...

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Bibliographic Details
Main Authors: Adenan, MI (Author), Cheema, MS (Author), Hambali, A (Author), Hamid, HA (Author), Hashim, NFM (Author), Kumar, J (Author), Maniam, S (Author), Mehat, MZ (Author), Mustapha, M (Author), Stanslas, J (Author)
Format: Article
Language:English
Published: 2021
Subjects:
Alzheimer's disease
AMYLOID PRECURSOR PROTEIN
BRAIN-BARRIER PERMEABILITY
Centella asiatica
CEREBRAL-BLOOD-FLOW
ELEMENT-BINDING PROTEIN
HEME OXYGENASE-1 EXPRESSION
hypoxia
INFLAMMATORY RESPONSE
MOUSE MODEL
neurodegenerative disease
neuroinflammation
neuroprotective
NF-kappa beta
NF-KAPPA-B
Nrf2
OXIDATIVE STRESS
UP-REGULATION
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