Animals 225 Rats animal rat 225 male 119 nonhuman 115 metabolism 111 controlled study 107 animal experiment 104 Article 102 Male 90 Sprague Dawley rat 77 Rats, Sprague-Dawley 76 animal tissue 67 animal model 63 human 63 Humans 59 female 50 drug effect 45 physiology 42 Female 39 chemistry 37 pathology 36 adult 35 mouse 33 animal cell 32 unclassified drug 32 Mice 29 genetics 29 plant extract 29