animal model 397 nonhuman 389 animal experiment 384 controlled study 338 Article 311 male 278 Animals 217 animal tissue 212 animal 200 mouse 194 rat 164 female 145 human 134 unclassified drug 116 Male 108 metabolism 104 animal cell 100 Mice 93 Humans 91 adult 89 in vivo study 84 article 79 Rats 78 protein expression 70 priority journal 63 Female 62 drug effect 61 genetics 59 histopathology 56 pathology 56