human 166 Humans 127 Article 117 female 95 male 90 controlled study 78 adult 74 Female 70 Male 63 Cell death 59 major clinical study 56 aged 46 death 44 mortality 41 cell death 40 middle aged 37 Aged 34 Middle Aged 34 metabolism 34 Adult 29 cause of death 29 cohort analysis 28 genetics 28 apoptosis 27 pathology 26 nonhuman 25 COVID-19 24 follow up 24 priority journal 24 programmed death 1 ligand 1 24