Customized yeast cell factories for biopharmaceuticals: from cell engineering to process scale up

by Aravind Madhavan, K. B. Arun, Raveendran Sindhu, Jayaram Krishnamoorthy, R. Reshmy, Ranjna Sirohi, Arivalagan Pugazhendi, Mukesh Kumar Awasthi, George Szakacs, Parameswaran Binod
Published 2021-06-01

Adaptive laboratory evolution accelerated glutarate production by Corynebacterium glutamicum

by Carina Prell, Tobias Busche, Christian Rückert, Lea Nolte, Christoph Brandenbusch, Volker F. Wendisch
Published 2021-05-01

Immune response induced by oral administration with a Saccharomyces cerevisiae-based SARS-CoV-2 vaccine in mice

by Tong Gao, Yi Ren, Shuangqin Li, Xin Lu, Han Lei
Published 2021-05-01

Genetic engineering of the precursor supply pathway for the overproduction of the nC14-surfactin isoform with promising MEOR applications

by Fangxiang Hu, Weijie Cai, Junzhang Lin, Weidong Wang, Shuang Li
Published 2021-05-01

Monitoring and external control of pH in microfluidic droplets during microbial culturing

by Miguel Tovar, Lisa Mahler, Stefanie Buchheim, Martin Roth, Miriam A. Rosenbaum
Published 2020-01-01

Investigation of Kluyveromyces marxianus as a novel host for large‐scale production of porcine parvovirus virus‐like particles

by Deqiang Yang, Lei Chen, Jinkun Duan, Yao Yu, Jungang Zhou, Hong Lu
Published 2021-01-01

Integrating pathway elucidation with yeast engineering to produce polpunonic acid the precursor of the anti-obesity agent celastrol

by Nikolaj L. Hansen, Karel Miettinen, Yong Zhao, Codruta Ignea, Aggeliki Andreadelli, Morten H. Raadam, Antonios M. Makris, Birger L. Møller, Dan Stærk, Søren Bak, Sotirios C. Kampranis
Published 2020-01-01

The effects of external Mn2+ concentration on hyphal morphology and citric acid production are mediated primarily by the NRAMP-family transporter DmtA in Aspergillus niger

by Balázs Fejes, Jean-Paul Ouedraogo, Erzsébet Fekete, Erzsébet Sándor, Michel Flipphi, Áron Soós, Ákos P. Molnár, Béla Kovács, Christian P. Kubicek, Adrian Tsang, Levente Karaffa
Published 2020-01-01

Purification and identification of a surfactin biosurfactant and engine oil degradation by Bacillus velezensis KLP2016

by Khem Raj Meena, Rajni Dhiman, Kailash Singh, Sachin Kumar, Abhishek Sharma, Shamsher S. Kanwar, Rittick Mondal, Sandip Das, Octavio L. Franco, Amit Kumar Mandal
Published 2021-01-01

Synergistic optimisation of expression, folding, and secretion improves E. coli AppA phytase production in Pichia pastoris

by Laura Navone, Thomas Vogl, Pawarisa Luangthongkam, Jo-Anne Blinco, Carlos Luna-Flores, Xiaojing Chen, Juhani von Hellens, Robert Speight
Published 2021-01-01

Screening for optimal protease producing Bacillus licheniformis strains with polymer-based controlled-release fed-batch microtiter plates

by Tobias Habicher, Tobias Klein, Jacqueline Becker, Andreas Daub, Jochen Büchs
Published 2021-02-01

Production of bio-xylitol from d-xylose by an engineered Pichia pastoris expressing a recombinant xylose reductase did not require any auxiliary substrate as electron donor

by Tai Man Louie, Kailin Louie, Samuel DenHartog, Sridhar Gopishetty, Mani Subramanian, Mark Arnold, Shuvendu Das
Published 2021-02-01

Enhancement of bleomycin production in Streptomyces verticillus through global metabolic regulation of N-acetylglucosamine and assisted metabolic profiling analysis

by Hong Chen, Jiaqi Cui, Pan Wang, Xin Wang, Jianping Wen
Published 2020-02-01

Effect of the TetR family transcriptional regulator Sp1418 on the global metabolic network of Saccharopolyspora pogona

by Haocheng He, Shuangqin Yuan, Jinjuan Hu, Jianming Chen, Jie Rang, Jianli Tang, Zhudong Liu, Ziyuan Xia, Xuezhi Ding, Shengbiao Hu, Liqiu Xia
Published 2020-02-01

Production of riboflavin and related cofactors by biotechnological processes

by Shuang Liu, Wenya Hu, Zhiwen Wang, Tao Chen
Published 2020-02-01

Heterologous caffeic acid biosynthesis in Escherichia coli is affected by choice of tyrosine ammonia lyase and redox partners for bacterial Cytochrome P450

by Kristina Haslinger, Kristala L. J. Prather
Published 2020-02-01

Direct RBS Engineering of the biosynthetic gene cluster for efficient productivity of violaceins in E. coli

by Yuyang Zhang, Hongping Chen, Yao Zhang, Huifang Yin, Chenyan Zhou, Yan Wang
Published 2021-02-01

Comparative transcriptomic analysis reveals the significant pleiotropic regulatory effects of LmbU on lincomycin biosynthesis

by Chun-Yan Lin, Ai-Ping Pang, Yue Zhang, Jianjun Qiao, Guang-Rong Zhao
Published 2020-02-01

Inducing secondary metabolite production of Aspergillus sydowii through microbial co-culture with Bacillus subtilis

by Yu Sun, Wen-Cai Liu, Xuan Shi, Hai-Zhou Zheng, Zhi-Hui Zheng, Xin-Hua Lu, Yan Xing, Kai Ji, Mei Liu, Yue-Sheng Dong
Published 2021-02-01

Optimal process design space to ensure maximum viability and productivity in Penicillium chrysogenum pellets during fed-batch cultivations through morphological and physiological c...

by Lukas Veiter, Julian Kager, Christoph Herwig
Published 2020-02-01