CRISPR-based antimicrobials to obstruct antibiotic-resistant and pathogenic bacteria.

by Dennise Palacios Araya, Kelli L Palmer, Breck A Duerkop
Published 2021-07-01

Genome-Wide fitness analysis of group B Streptococcus in human amniotic fluid reveals a transcription factor that controls multiple virulence traits.

by Allison N Dammann, Anna B Chamby, Andrew J Catomeris, Kyle M Davidson, Hervé Tettelin, Jan-Peter van Pijkeren, Kathyayini P Gopalakrishna, Mary F Keith, Jordan L Elder, Adam J Ratner, Thomas A Hooven
Published 2021-03-01

Population genomics of the pathogenic yeast Candida tropicalis identifies hybrid isolates in environmental samples.

by Caoimhe E O'Brien, João Oliveira-Pacheco, Eoin Ó Cinnéide, Max A B Haase, Chris Todd Hittinger, Thomas R Rogers, Oscar Zaragoza, Ursula Bond, Geraldine Butler
Published 2021-03-01

A plant reovirus hijacks endoplasmic reticulum-associated degradation machinery to promote efficient viral transmission by its planthopper vector under high temperature conditions.

by Xiangzhen Yu, Dongsheng Jia, Zhen Wang, Guangjun Li, Manni Chen, Qifu Liang, Yanyan Zhou, Huan Liu, Mi Xiao, Siting Li, Qian Chen, Hongyan Chen, Taiyun Wei
Published 2021-03-01

Ferroptosis and microbial pathogenesis.

by Qing Shen, Naweed I Naqvi
Published 2021-03-01

The granuloma in cryptococcal disease.

by Laura C Ristow, J Muse Davis
Published 2021-03-01

Procyclic trypanosomes recycle glucose catabolites and TCA cycle intermediates to stimulate growth in the presence of physiological amounts of proline.

by Oriana Villafraz, Marc Biran, Erika Pineda, Nicolas Plazolles, Edern Cahoreau, Rodolpho Ornitz Oliveira Souza, Magali Thonnus, Stefan Allmann, Emmanuel Tetaud, Loïc Rivière, Ariel M Silber, Michael P Barrett, Alena Zíková, Michael Boshart, Jean-Charles Portais, Frédéric Bringaud
Published 2021-03-01

Tissue-specific transcriptional profiling of plasmacytoid dendritic cells reveals a hyperactivated state in chronic SIV infection.

by Michelle Y-H Lee, Amit A Upadhyay, Hasse Walum, Chi N Chan, Reem A Dawoud, Christine Grech, Justin L Harper, Kirti A Karunakaran, Sydney A Nelson, Ernestine A Mahar, Kyndal L Goss, Diane G Carnathan, Barbara Cervasi, Kiran Gill, Gregory K Tharp, Elizabeth R Wonderlich, Vijayakumar Velu, Simon M Barratt-Boyes, Mirko Paiardini, Guido Silvestri, Jacob D Estes, Steven E Bosinger
Published 2021-06-01

PD-1 is imprinted on cytomegalovirus-specific CD4+ T cells and attenuates Th1 cytokine production whilst maintaining cytotoxicity.

by Helen M Parry, Alexander C Dowell, Jianmin Zuo, Kriti Verma, Francesca A M Kinsella, Jusnara Begum, Wayne Croft, Archana Sharma-Oates, Guy Pratt, Paul Moss
Published 2021-03-01

Symbiotic bracovirus of a parasite manipulates host lipid metabolism via tachykinin signaling.

by Yanping Wang, Xiaotong Wu, Zehua Wang, Ting Chen, Sicong Zhou, Jiani Chen, Lan Pang, Xiqian Ye, Min Shi, Jianhua Huang, Xuexin Chen
Published 2021-03-01

Determining Aspergillus fumigatus transcription factor expression and function during invasion of the mammalian lung.

by Hong Liu, Wenjie Xu, Vincent M Bruno, Quynh T Phan, Norma V Solis, Carol A Woolford, Rachel L Ehrlich, Amol C Shetty, Carrie McCraken, Jianfeng Lin, Michael J Bromley, Aaron P Mitchell, Scott G Filler
Published 2021-03-01

Two human antibodies to a meningococcal serogroup B vaccine antigen enhance binding of complement Factor H by stabilizing the Factor H binding site.

by Nathaniel A Sands, Peter T Beernink
Published 2021-06-01

Aerobic glycolysis supports hepatitis B virus protein synthesis through interaction between viral surface antigen and pyruvate kinase isoform M2.

by Yi-Hsuan Wu, Yi Yang, Ching-Hung Chen, Chia-Jen Hsiao, Tian-Neng Li, Kuan-Ju Liao, Koichi Watashi, Bor-Sen Chen, Lily Hui-Ching Wang
Published 2021-03-01

Innate immune signatures to a partially-efficacious HIV vaccine predict correlates of HIV-1 infection risk.

by Erica Andersen-Nissen, Andrew Fiore-Gartland, Lamar Ballweber Fleming, Lindsay N Carpp, Anneta F Naidoo, Michael S Harper, Valentin Voillet, Nicole Grunenberg, Fatima Laher, Craig Innes, Linda-Gail Bekker, James G Kublin, Ying Huang, Guido Ferrari, Georgia D Tomaras, Glenda Gray, Peter B Gilbert, M Juliana McElrath
Published 2021-03-01

The CDT of Helicobacter hepaticus induces pro-survival autophagy and nucleoplasmic reticulum formation concentrating the RNA binding proteins UNR/CSDE1 and P62/SQSTM1.

by Wencan He, Lamia Azzi-Martin, Valérie Velasco, Philippe Lehours, Pierre Dubus, Mojgan Djavaheri-Mergny, Armelle Ménard
Published 2021-03-01

The allelic rice immune receptor Pikh confers extended resistance to strains of the blast fungus through a single polymorphism in the effector binding interface.

by Juan Carlos De la Concepcion, Josephine H R Maidment, Apinya Longya, Gui Xiao, Marina Franceschetti, Mark J Banfield
Published 2021-03-01

House dust mite sensitization drives cross-reactive immune responses to homologous helminth proteins.

by Pedro Henrique Gazzinelli-Guimaraes, Sasisekhar Bennuru, Rafael de Queiroz Prado, Alessandra Ricciardi, Joshua Sciurba, Jonah Kupritz, Matthew Moser, Olena Kamenyeva, Thomas B Nutman
Published 2021-03-01

Odour of domestic dogs infected with Leishmania infantum is attractive to female but not male sand flies: Evidence for parasite manipulation.

by Monica E Staniek, James G C Hamilton
Published 2021-03-01

Glycoprotein N-linked glycans play a critical role in arenavirus pathogenicity.

by Takaaki Koma, Cheng Huang, Adrian Coscia, Steven Hallam, John T Manning, Junki Maruyama, Aida G Walker, Milagros Miller, Jeanon N Smith, Michael Patterson, Jonathan Abraham, Slobodan Paessler
Published 2021-03-01

Genomic characterization of 99 viruses from the bunyavirus families Nairoviridae, Peribunyaviridae, and Phenuiviridae, including 35 previously unsequenced viruses.

by Marylee L Kapuscinski, Nicholas A Bergren, Brandy J Russell, Justin S Lee, Erin M Borland, Daniel A Hartman, David C King, Holly R Hughes, Kristen L Burkhalter, Rebekah C Kading, Mark D Stenglein
Published 2021-03-01