somatic mutation 17 human 16 Article 12 Humans 12 Mutation 9 female 8 genetics 8 Female 7 controlled study 7 male 7 mutation 7 Male 6 adult 6 gene mutation 5 middle aged 5 nonhuman 5 whole exome sequencing 5 Middle Aged 4 gene frequency 4 high throughput sequencing 4 major clinical study 4 Breast Neoplasms 3 Cancer 3 DNA sequence 3 Genomics 3 Somatic mutation 3 aged 3 bioinformatics 3 breast cancer 3 breast tumor 3