The Pre-Diabetes Interventions and Continued Tracking to Ease-out Diabetes (Pre-DICTED) program: study protocol for a randomized controlled trial

by Kar-Fu Yeung, Mihir Gandhi, Amanda Yun Rui Lam, Selly Julianty, Alvin Yeow Meng Chia, Gilbert Choon Seng Tan, Su-Yen Goh, Emily Tse Lin Ho, Angela Fang Yung Koh, Gavin Siew Wei Tan, Eugene Jin Wen Shum, Eric A. Finkelstein, Tazeen H. Jafar, Yee Leong Teoh, Rob M. van Dam, Clare Whitton, Julian Thumboo, Yong Mong Bee
Published 2021-08-01

Financial Incentives for Preventing Postpartum return to Smoking (FIPPS): study protocol for a three-arm randomised controlled trial

by M. Ussher, C. Best, S. Lewis, J. McKell, T. Coleman, S. Cooper, S. Orton, L. Bauld
Published 2021-08-01

Comparing two fluoride therapies for caries management in young children: study protocol for a randomised clinical trial

by Sherry Shiqian Gao, Faith Miaomiao Zheng, Kitty Jieyi Chen, Duangporn Duangthip, Edward Chin Man Lo, Chun Hung Chu
Published 2021-08-01

The implications of outcome truncation in reproductive medicine RCTs: a simulation platform for trialists and simulation study

by Jack Wilkinson, Jonathan Y. Huang, Antonia Marsden, Michael O. Harhay, Andy Vail, Stephen A. Roberts
Published 2021-08-01

A systematic review of endpoint definitions in late phase pulmonary tuberculosis therapeutic trials

by N. K. Hills, J. Lyimo, P. Nahid, R. M. Savic, C. Lienhardt, P. P. J. Phillips
Published 2021-08-01

Efficacy of low-load resistance training combined with blood flow restriction vs. high-load resistance training on sarcopenia among community-dwelling older Chinese people: study p...

by Nan Chen, Xiangfeng He, Guoyun Zhao, Linqian Lu, Barbara E. Ainsworth, Yu Liu, Xie Wu
Published 2021-08-01

Using a BonE BiOPsy (BeBoP) to determine the causative agent in persons with diabetes and foot osteomyelitis: study protocol for a multicentre, randomised controlled trial

by Meryl Cinzía Tila Tamara Gramberg, Rimke Sabine Lagrand, Louise Willy Elizabeth Sabelis, Martin den Heijer, Vincent de Groot, Max Nieuwdorp, Willemijn Kortmann, Elske Sieswerda, Edgar Josephus Gerardus Peters
Published 2021-08-01

Rapid deployment of a community engagement study and educational trial via social media: implementation of the UC-COVID study

by Lauren E. Wisk, Russell G. Buhr
Published 2021-08-01

Green tea intake and its effect on laboratory parameters and disease symptoms in hospitalised patients with Covid 19: a structured protocol for a randomized controlled trial

by Sara Mahmoodi, Mojtaba Yousefi, Omid Sadeghi, Ali Mahmoodabadi, Mohammadreza Sadriirani, Zahra Hosseinzade, Abdolhossein Jahanbakhsh, Seyed Bahman Panahande, Zaker Saeedinejad, Jan Mohamad Malekzadeh, Mohsen Naghmachi, Azizollah Pourmahmoudi
Published 2021-08-01

The efficacy of Tuina with herbal ointment for patients with post-stroke depression: study protocol for a randomized controlled trial

by Jiming Tao, Lingjun Kong, Min Fang, Qingguang Zhu, Shuaipan Zhang, Sicong Zhang, Jiajia Wu, Chunlei Shan, Ling Feng, Qingjuan Guo, Zhiwei Wu
Published 2021-07-01

REBOARREST, resuscitative endovascular balloon occlusion of the aorta in non-traumatic out-of-hospital cardiac arrest: a study protocol for a randomised, parallel group, clinical m...

by Jostein Rødseth Brede, Arne Kristian Skulberg, Marius Rehn, Kjetil Thorsen, Pål Klepstad, Ida Tylleskär, Bjørn Farbu, Jostein Dale, Trond Nordseth, Rune Wiseth, Andreas Jørstad Krüger
Published 2021-07-01

The Chinese herbal formula Huoxiang Zhengqi for diarrhea-predominant irritable bowel syndrome (CHAIRS): a study protocol for a double-blinded randomized controlled trial

by Xiaohui Guo, Meiling Xuan, Huan Zheng, Shumin Qin, Haomeng Wu, Shaogang Huang, Zehuai Wen
Published 2021-07-01

The TANDEM trial: protocol for the process evaluation of a randomised trial of a complex intervention for anxiety and/or depression in people living with chronic obstructive pulmon...

by Moira Kelly, Liz Steed, Ratna Sohanpal, Hilary Pinnock, Amy Barradell, Clarisse Dibao-Dina, Kristie-Marie Mammoliti, Vari Wileman, Vickie Rowland, Sian Newton, Anna Moore, Stephanie Taylor
Published 2021-07-01

Effect of GreenshellTM mussel on osteoarthritis biomarkers and inflammation in healthy postmenopausal women: a study protocol for a randomized double-blind placebo-controlled trial...

by Maryam Abshirini, Jane Coad, Frances M. Wolber, Pamela von Hurst, Matthew R. Miller, Hong Sabrina Tian, Marlena C. Kruger
Published 2021-07-01

An Investigation of Levetiracetam in Alzheimer’s Disease (ILiAD): a double-blind, placebo-controlled, randomised crossover proof of concept study

by Arjune Sen, Mary Akinola, Xin You Tai, Mkael Symmonds, Gabriel Davis Jones, Sergio Mura, Joanne Galloway, Angela Hallam, Jane Y. C. Chan, Ivan Koychev, Chris Butler, John Geddes, Rohan Van Der Putt, Sian Thompson, Sanjay G. Manohar, Eleni Frangou, Sharon Love, Rupert McShane, Masud Husain
Published 2021-07-01

The Community PrEP Study: a randomized control trial leveraging community-based platforms to improve access and adherence to pre-exposure prophylaxis to prevent HIV among adolescen...

by Andrew Medina-Marino, Dana Bezuidenhout, Sybil Hosek, Ruanne V. Barnabas, Millicent Atujuna, Charl Bezuidenhout, Phuti Ngwepe, Remco P.H. Peters, Francesca Little, Connie L. Celum, Joseph Daniels, Linda-Gail Bekker
Published 2021-07-01

A digital health peri-operative cognitive-behavioral intervention to prevent transition from acute to chronic postsurgical pain in adolescents undergoing spinal fusion (SurgeryPalT...

by Jennifer A. Rabbitts, Chuan Zhou, Rocio de la Vega, Homer Aalfs, Caitlin B. Murray, Tonya M. Palermo
Published 2021-07-01

Patient and public involvement in numerical aspects of trials (PoINT): exploring patient and public partners experiences and identifying stakeholder priorities

by Beatriz Goulao, Hanne Bruhn, Marion Campbell, Craig Ramsay, Katie Gillies
Published 2021-07-01

COVEPIC (Cognitive and spOrt Virtual EPIC training) investigating the effects of home-based physical exercise and cognitive training on cognitive and physical functions in communit...

by Emma Gabrielle Dupuy, Florent Besnier, Christine Gagnon, Thomas Vincent, Catherine-Alexandra Grégoire, Caroll-Ann Blanchette, Kathia Saillant, Nadia Bouabdallaoui, Josep Iglesies-Grau, Marie Payer, Marie-France Marin, Sylvie Belleville, Martin Juneau, Paolo Vitali, Mathieu Gayda, Anil Nigam, Louis Bherer
Published 2021-07-01

Effects of an exclusive human-milk diet in preterm neonates on early vascular aging risk factors (NEOVASC): study protocol for a multicentric, prospective, randomized, controlled,...

by Wolfgang Mitterer, Christoph Binder, Anya Blassnig-Ezeh, Lorenz Auer-Hackenberg, Angelika Berger, Burkhard Simma, Martin Wald, Martin Lee, Ursula Kiechl-Kohlendorfer
Published 2021-07-01