Brain Peak Width of Skeletonized Mean Diffusivity (PSMD) and Cognitive Function in Later Life

by Ian J. Deary, Ian J. Deary, Stuart J. Ritchie, Stuart J. Ritchie, Stuart J. Ritchie, Susana Muñoz Maniega, Susana Muñoz Maniega, Susana Muñoz Maniega, Simon R. Cox, Simon R. Cox, Simon R. Cox, Maria C. Valdés Hernández, Maria C. Valdés Hernández, Maria C. Valdés Hernández, Maria C. Valdés Hernández, Michelle Luciano, Michelle Luciano, John M. Starr, John M. Starr, Joanna M. Wardlaw, Joanna M. Wardlaw, Joanna M. Wardlaw, Joanna M. Wardlaw, Mark E. Bastin, Mark E. Bastin, Mark E. Bastin
Published 2019-07-01

A unified resource and configurable model of the synapse proteome and its role in disease

by Oksana Sorokina, Colin Mclean, Mike D. R. Croning, Katharina F. Heil, Emilia Wysocka, Xin He, David Sterratt, Seth G. N. Grant, Thomas I. Simpson, J. Douglas Armstrong
Published 2021-05-01

Therapeutic Targeting of Proteostasis in Amyotrophic Lateral Sclerosis—a Systematic Review and Meta-Analysis of Preclinical Research

by Elizabeth Elliott, Elizabeth Elliott, Elizabeth Elliott, Elizabeth Elliott, Elizabeth Elliott, Elizabeth Elliott, Olivia Bailey, Olivia Bailey, Olivia Bailey, Fergal M. Waldron, Giles E. Hardingham, Giles E. Hardingham, Giles E. Hardingham, Siddharthan Chandran, Siddharthan Chandran, Siddharthan Chandran, Siddharthan Chandran, Siddharthan Chandran, Siddharthan Chandran, Siddharthan Chandran, Siddharthan Chandran, Jenna M. Gregory, Jenna M. Gregory, Jenna M. Gregory, Jenna M. Gregory, Jenna M. Gregory, Jenna M. Gregory, Jenna M. Gregory
Published 2020-05-01

Regional variation in health is predominantly driven by lifestyle rather than genetics

by Carmen Amador, Charley Xia, Réka Nagy, Archie Campbell, David Porteous, Blair H. Smith, Nick Hastie, Veronique Vitart, Caroline Hayward, Pau Navarro, Chris S. Haley
Published 2017-10-01

The Lothian Diary Project: Investigating the Impact of the COVID-19 Pandemic on Edinburgh and Lothian Residents

by Lauren Hall-Lew, Claire Cowie, Stephen Joseph McNulty, Nina Markl, Shan-Jan Sarah Liu, Catherine Lai, Clare Llewellyn, Beatrice Alex, Nini Fang, Zuzana Elliott, Anita Klingler
Published 2021-04-01

Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways

by David M. Howard, Mark J. Adams, Masoud Shirali, Toni-Kim Clarke, Riccardo E. Marioni, Gail Davies, Jonathan R. I. Coleman, Clara Alloza, Xueyi Shen, Miruna C. Barbu, Eleanor M. Wigmore, Jude Gibson, 23andMe Research Team, Saskia P. Hagenaars, Cathryn M. Lewis, Joey Ward, Daniel J. Smith, Patrick F. Sullivan, Chris S. Haley, Gerome Breen, Ian J. Deary, Andrew M. McIntosh
Published 2018-04-01

Targeted de-repression of neuronal Nrf2 inhibits α-synuclein accumulation

by Paul S. Baxter, Nóra M. Márkus, Owen Dando, Xin He, Bashayer R. Al-Mubarak, Jing Qiu, Giles E. Hardingham
Published 2021-02-01

αv integrins on mesenchymal cells regulate skeletal and cardiac muscle fibrosis

by I. R. Murray, Z. N. Gonzalez, J. Baily, R. Dobie, R. J. Wallace, A. C. Mackinnon, J. R. Smith, S. N. Greenhalgh, A. I. Thompson, K. P. Conroy, D. W. Griggs, P. G. Ruminski, G. A. Gray, M. Singh, M. A. Campbell, T. J. Kendall, J. Dai, Y. Li, J. P. Iredale, H. Simpson, J. Huard, B. Péault, N. C. Henderson
Published 2017-10-01

Using regulatory variants to detect gene–gene interactions identifies networks of genes linked to cell immortalisation

by D. Wragg, Q. Liu, Z. Lin, V. Riggio, C. A. Pugh, A. J. Beveridge, H. Brown, D. A. Hume, S. E. Harris, I. J. Deary, A. Tenesa, J. G. D. Prendergast
Published 2020-01-01

Evidence for evolutionary divergence of activity-dependent gene expression in developing neurons

by Jing Qiu, Jamie McQueen, Bilada Bilican, Owen Dando, Dario Magnani, Karolina Punovuori, Bhuvaneish T Selvaraj, Matthew Livesey, Ghazal Haghi, Samuel Heron, Karen Burr, Rickie Patani, Rinku Rajan, Olivia Sheppard, Peter C Kind, T Ian Simpson, Victor LJ Tybulewicz, David JA Wyllie, Elizabeth MC Fisher, Sally Lowell, Siddharthan Chandran, Giles E Hardingham
Published 2016-10-01

Ageing and brain white matter structure in 3,513 UK Biobank participants

by Simon R. Cox, Stuart J. Ritchie, Elliot M. Tucker-Drob, David C. Liewald, Saskia P. Hagenaars, Gail Davies, Joanna M. Wardlaw, Catharine R. Gale, Mark E. Bastin, Ian J. Deary
Published 2016-12-01

A systematic review of the effectiveness, cost-effectiveness and barriers to implementation of thrombolytic and neuroprotective therapy for acute ischaemic stroke in the NHS

by P. Sandercock, E. Berge, M. Dennis, J. Forbes, P. Hand, J. Kwan, S. Lewis, R. Lindley, A. Neilson, B. Thomas, J. Wardlaw
Published 2002-01-01

Embryonic mesothelial-derived hepatic lineage of quiescent and heterogenous scar-orchestrating cells defined but suppressed by WT1

by Timothy James Kendall, Catherine Mary Duff, Luke Boulter, David H. Wilson, Elisabeth Freyer, Stuart Aitken, Stuart John Forbes, John Peter Iredale, Nicholas Dixon Hastie
Published 2019-10-01

A chicken bioreactor for efficient production of functional cytokines

by Lissa R. Herron, Clare Pridans, Matthew L. Turnbull, Nikki Smith, Simon Lillico, Adrian Sherman, Hazel J. Gilhooley, Martin Wear, Dominic Kurian, Grigorios Papadakos, Paul Digard, David A. Hume, Andrew C. Gill, Helen M. Sang
Published 2018-12-01

Microglial identity and inflammatory responses are controlled by the combined effects of neurons and astrocytes

by Paul S. Baxter, Owen Dando, Katie Emelianova, Xin He, Sean McKay, Giles E. Hardingham, Jing Qiu
Published 2021-03-01

Birth weight is associated with brain tissue volumes seven decades later but not with MRI markers of brain ageing

by Emily Wheater, Susan D. Shenkin, Susana Muñoz Maniega, Maria Valdés Hernández, Joanna M. Wardlaw, Ian J. Deary, Mark E. Bastin, James P. Boardman, Simon R. Cox
Published 2021-01-01

Computational quantification of brain perivascular space morphologies: Associations with vascular risk factors and white matter hyperintensities. A study in the Lothian Birth Cohor...

by Lucia Ballerini, Tom Booth, Maria del C. Valdés Hernández, Stewart Wiseman, Ruggiero Lovreglio, Susana Muñoz Maniega, Zoe Morris, Alison Pattie, Janie Corley, Alan Gow, Mark E. Bastin, Ian J. Deary, Joanna Wardlaw
Published 2020-01-01

Long-term cilostazol treatment reduces gliovascular damage and memory impairment in a mouse model of chronic cerebral hypoperfusion

by Akihiro Kitamura, Yasmina Manso, Jessica Duncombe, James Searcy, Juraj Koudelka, Margaret Binnie, Scott Webster, Ross Lennen, Maurits Jansen, Ian Marshall, Masafumi Ihara, Raj N. Kalaria, Karen Horsburgh
Published 2017-06-01

A fluorogenic cyclic peptide for imaging and quantification of drug-induced apoptosis

by Nicole D. Barth, Ramon Subiros-Funosas, Lorena Mendive-Tapia, Rodger Duffin, Mario A. Shields, Jennifer A. Cartwright, Sónia Troeira Henriques, Jesus Sot, Felix M. Goñi, Rodolfo Lavilla, John A. Marwick, Sonja Vermeren, Adriano G. Rossi, Mikala Egeblad, Ian Dransfield, Marc Vendrell
Published 2020-08-01

scRNA Transcription Profile of Adult Zebrafish Podocytes Using a Novel Reporter Strain

by Cara Brown, Linda J. Mullins, Katrina Wesencraft, Gail McConnell, Mariana Beltran, Neil C. Henderson, Bryan Conway, Scott Hoffmann, Sebastian Rider, John J. Mullins
Published 2021-05-01