human 334 Costs 299 Humans 255 Article 220 Cost effectiveness 185 female 176 adult 168 male 168 health care cost 164 controlled study 136 economics 116 major clinical study 108 Female 107 United States 107 Male 103 Cost benefit analysis 98 cost benefit analysis 96 Cost-Benefit Analysis 83 middle aged 83 cost effectiveness analysis 81 Adult 77 aged 77 Low-costs 70 Middle Aged 67 article 61 Commerce 60 drug cost 57 retrospective study 52 Cost reduction 51 Health Care Costs 49