Article 108 human 101 controlled study 93 Humans 85 reverse transcription polymerase chain reaction 82 male 60 nonhuman 59 female 58 genetics 56 adult 54 real time reverse transcription polymerase chain reaction 51 unclassified drug 44 gene expression 41 Male 40 Female 38 middle aged 35 metabolism 34 Middle Aged 33 major clinical study 31 human cell 30 protein expression 30 COVID-19 27 SARS-CoV-2 27 coronavirus disease 2019 27 animal experiment 25 upregulation 25 Western blotting 24 Animals 22 down regulation 22 mouse 22