biological marker human 87 Humans 80 Biomarkers 66 Article 59 male 55 female 54 Female 46 Male 46 controlled study 46 metabolism 41 adult 40 major clinical study 34 middle aged 32 Middle Aged 31 aged 27 blood 27 Aged 26 Adult 25 genetics 25 pathology 23 human cell 19 receiver operating characteristic 17 unclassified drug 17 gene expression 16 Animals 14 animal 14 nonhuman 14 protein expression 14 C reactive protein 13