down regulation Article 92 controlled study 78 human 74 upregulation 63 genetics 59 Humans 57 unclassified drug 57 gene expression 50 male 50 female 49 metabolism 46 adult 41 gene expression regulation 40 human cell 39 nonhuman 39 Female 33 human tissue 31 protein expression 30 Male 29 pathology 27 real time polymerase chain reaction 26 animal experiment 24 in vitro study 24 signal transduction 23 Cell Line, Tumor 22 Gene Expression Regulation, Neoplastic 22 Western blotting 22 major clinical study 22 tumor cell line 22