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1by Helle Bogetofte, Helle Bogetofte, Pia Jensen, Matias Ryding, Sissel I. Schmidt, Justyna Okarmus, Louise Ritter, Christina S. Worm, Michaela C. Hohnholt, Carla Azevedo, Laurent Roybon, Lasse K. Bak, Helle Waagepetersen, Brent J. Ryan, Richard Wade-Martins, Martin R. Larsen, Morten Meyer, Morten Meyer“... on the mitochondrial proteome in human isogenic induced pluripotent stem cell-derived neurons with and without PARK2...”
Published 2019-07-01
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2by Devika Agarwal, Cynthia Sandor, Viola Volpato, Tara M. Caffrey, Jimena Monzón-Sandoval, Rory Bowden, Javier Alegre-Abarrategui, Richard Wade-Martins, Caleb Webber“... the authors provide a single cell transcriptomic atlas for the human substantia nigra....”
Published 2020-08-01
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3by Mariana Vargas-Caballero, Richard Wade-Martins, Franziska Denk, Franziska Denk, Heike J. Wobst, Heike J. Wobst, Emily Arch, Chrysia-Maria Pegasiou, Peter L. Oliver, Olivia A. Shipton, Olivia A. Shipton, Ole Paulsen“... of hippocampal long-term potentiation (LTP) in mice requires tau. Here, we asked whether expression of human MAPT...”
Published 2017-04-01
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4by Helle Bogetofte, Pia Jensen, Justyna Okarmus, Sissel Ida Schmidt, Mikkel Agger, Matias Ryding, Peter Nørregaard, Christina Fenger, Xianmin Zeng, Jesper Graakjær, Brent James Ryan, Richard Wade-Martins, Martin Røssel Larsen, Morten Meyer“...), but dysfunctional parkin has also been implicated in sporadic PD. By combining human isogenic induced pluripotent...”
Published 2019-12-01
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5by Christa Überbacher, Julia Obergasteiger, Mattia Volta, Serena Venezia, Stefan Müller, Isabella Pesce, Sara Pizzi, Giulia Lamonaca, Anne Picard, Giada Cattelan, Giorgio Malpeli, Michele Zoli, Dayne Beccano-Kelly, Rowan Flynn, Richard Wade-Martins, Peter P. Pramstaller, Andrew A. Hicks, Sally A. Cowley, Corrado Corti“...Human induced pluripotent stem cells (hiPSCs) have become indispensable for disease modelling...”
Published 2019-12-01
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6by Walther Haenseler, Stephen N. Sansom, Julian Buchrieser, Sarah E. Newey, Craig S. Moore, Francesca J. Nicholls, Satyan Chintawar, Christian Schnell, Jack P. Antel, Nicholas D. Allen, M. Zameel Cader, Richard Wade-Martins, William S. James, Sally A. CowleySubjects: “...human...”
Published 2017-06-01
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7by Benjamin H.M. Hunn, Siv Vingill, Sarah Threlfell, Javier Alegre-Abarrategui, Morgane Magdelyns, Thierry Deltheil, Nora Bengoa-Vergniory, Peter L. Oliver, Milena Cioroch, Natalie M. Doig, David M. Bannerman, Stephanie J. Cragg, Richard Wade-Martins“... and activation of autophagy proposed as a treatment strategy. We generate a human α-synuclein-expressing mouse...”
Published 2019-10-01
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8by Nora Bengoa-Vergniory, Emilie Faggiani, Paula Ramos-Gonzalez, Ecem Kirkiz, Natalie Connor-Robson, Liam V. Brown, Ibrar Siddique, Zizheng Li, Siv Vingill, Milena Cioroch, Fabio Cavaliere, Sarah Threlfell, Bradley Roberts, Thomas Schrader, Frank-Gerrit Klärner, Stephanie Cragg, Benjamin Dehay, Gal Bitan, Carlos Matute, Erwan Bezard, Richard Wade-Martins“... protects dopaminergic neurons in vitro and in vivo in human neurons and in mouse models showing potential...”
Published 2020-09-01
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9by Tonya N. Taylor, Dawid Potgieter, Sabina Anwar, Steven L. Senior, Stephanie Janezic, Sarah Threlfell, Brent Ryan, Laura Parkkinen, Thierry Deltheil, Milena Cioroch, Achilleas Livieratos, Peter L. Oliver, Katie A. Jennings, Kay E. Davies, Olaf Ansorge, David M. Bannerman, Stephanie J. Cragg, Richard Wade-Martins“... transgenic model of PD. We expressed the A30P mutant form of human α-synuclein in a spatially-relevant manner...”
Published 2014-02-01
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10by Sarah Threlfell, Sarah Threlfell, Amir Saeid Mohammadi, Brent J. Ryan, Brent J. Ryan, Natalie Connor-Robson, Natalie Connor-Robson, Nicola J. Platt, Rishi Anand, Florence Serres, Trevor Sharp, Nora Bengoa-Vergniory, Nora Bengoa-Vergniory, Richard Wade-Martins, Richard Wade-Martins, Andrew Ewing, Stephanie J. Cragg, Stephanie J. Cragg, Katherine R. Brimblecombe, Katherine R. Brimblecombe“..., we tested whether DAT function in governing dopamine (DA) uptake and release is modified in a human-α...”
Published 2021-04-01
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11by Julia Benkert, Simon Hess, Shoumik Roy, Dayne Beccano-Kelly, Nicole Wiederspohn, Johanna Duda, Carsten Simons, Komal Patil, Aisylu Gaifullina, Nadja Mannal, Elena Dragicevic, Desirée Spaich, Sonja Müller, Julia Nemeth, Helene Hollmann, Nora Deuter, Yassine Mousba, Christian Kubisch, Christina Poetschke, Joerg Striessnig, Olaf Pongs, Toni Schneider, Richard Wade-Martins, Sandip Patel, Rosanna Parlato, Tobias Frank, Peter Kloppenburg, Birgit LissGet full text
Published 2019-11-01
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12by Alastair G Kerr, Lawrence CS Tam, Ashley B Hale, Milena Cioroch, Gillian Douglas, Keith M Channon, Richard Wade-Martins“... essential for regulated expression. Here, we have combined a minigene vector expressing the human LDLR cDNA...”
Published 2016-01-01
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13by David Gordon, Ruxandra Dafinca, Jakub Scaber, Javier Alegre-Abarrategui, Lucy Farrimond, Connor Scott, Daniel Biggs, Louisa Kent, Peter L. Oliver, Benjamin Davies, Olaf Ansorge, Richard Wade-Martins, Kevin Talbot“... of human ALS, but may also lead to non-specific toxicity. To avoid the potentially confounding effects...”
Published 2019-01-01
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14by Natalie Connor-Robson, Heather Booth, Jeffrey G. Martin, Benbo Gao, Kejie Li, Natalie Doig, Jane Vowles, Cathy Browne, Laura Klinger, Peter Juhasz, Christine Klein, Sally A. Cowley, Paul Bolam, Warren Hirst, Richard Wade-Martins“..., and post-mortem human brain tissue from LRRK2-G2019S patients. Results: Our integrated -omics analysis...”
Published 2019-07-01
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15by Nora Bengoa-Vergniory, Elisavet Velentza-Almpani, Ana Maria Silva, Connor Scott, Mariana Vargas-Caballero, Magdalena Sastre, Richard Wade-Martins, Javier Alegre-Abarrategui“...-proximity ligation assay (tau-PLA). We then analyzed MAPT KO and P301S transgenic mice, and human...”
Published 2021-01-01
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17“...Microbiota have increasingly become implicated in predisposition to human diseases, including...”
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18by Heather D.E. Booth, Frank Wessely, Natalie Connor-Robson, Federica Rinaldi, Jane Vowles, Cathy Browne, Samuel G. Evetts, Michele T. Hu, Sally A. Cowley, Caleb Webber, Richard Wade-Martins“...-patterned astrocytes from human induced pluripotent stem cells (iPSCs) derived from PD LRRK2 G2019S patients...”
Published 2019-09-01
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