Showing 1 - 20 results of 26 for search 'PHARMACEUTICAL ANALYSIS', query time: 1.68s Refine Results
  1. 1
    Reversal Effect of ALK Inhibitor NVP-TAE684 on ABCG2-Overexpressing Cancer Cells
    “... was conducted to determine the impact of NVP-TAE684 on ATP hydrolysis. Western blot analysis...”
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    Article
  2. 2
    Overexpression of ABCB1 Transporter Confers Resistance to mTOR Inhibitor WYE-354 in Cancer Cells
    “... to determine the impact of WYE-354 on ATP hydrolysis. Western blot analysis and immunofluorescence assay were...”
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    Article
  3. 3
    Characterization of a novel HDAC/RXR/HtrA1 signaling axis as a novel target to overcome cisplatin resistance in human non-small cell lung cancer
    “... of the HDAC/RXR/HtrA1 signaling axis in cisplatin resistance, and luciferase reporter analysis and ChIP assays...”
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    Article
  4. 4
    Elevated ABCB1 Expression Confers Acquired Resistance to Aurora Kinase Inhibitor GSK-1070916 in Cancer Cells
    “... in the computational docking analysis. In conclusion, our study provides strong evidence that ABCB1 can confer...”
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    Article
  5. 5
    Ciprofloxacin Enhances the Chemosensitivity of Cancer Cells to ABCB1 Substrates
    “... of ciprofloxacin on the ATPase activity of ABCB1, and docking analysis was done to determine the interaction...”
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    Article
  6. 6
    VS-4718 Antagonizes Multidrug Resistance in ABCB1- and ABCG2-Overexpressing Cancer Cells by Inhibiting the Efflux Function of ABC Transporters
    “... to attenuation of the efflux activity of ABCB1 and ABCG2 transporters. ATPase analysis indicated that VS-4718...”
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    Article
  7. 7
    Overexpression of ABCG2 Confers Resistance to MLN7243, a Ubiquitin-Activating Enzyme (UAE) Inhibitor
    “... analysis also implied that MLN7243 binds to ABCG2 drug-binding pocket with optimal binding affinity...”
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    Article
  8. 8
    Reversal of Cancer Multidrug Resistance (MDR) Mediated by ATP-Binding Cassette Transporter G2 (ABCG2) by AZ-628, a RAF Kinase Inhibitor
    “...-dependent manner. Docking and molecular dynamics simulation analysis showed that AZ-628 binds to the same...”
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    Article
  9. 9
    M3814, a DNA-PK Inhibitor, Modulates ABCG2-Mediated Multidrug Resistance in Lung Cancer Cells
    “.... Moreover, the molecular docking analysis indicated a high affinity between M3814 and ABCG2 transporter...”
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    Article
  10. 10
    Tivantinib, A c-Met Inhibitor in Clinical Trials, Is Susceptible to ABCG2-Mediated Drug Resistance
    “... received a high score in docking analysis, indicating a strong interaction between tivantinib and ABCG2...”
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    Article
  11. 11
    OTS964, a TOPK Inhibitor, Is Susceptible to ABCG2-Mediated Drug Resistance
    “... analysis combined with results from ATPase assay suggested that OTS964 interacts with drug-binding pocket...”
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    Article
  12. 12
    Establishment and characterization of arsenic trioxide resistant KB/ATO cells
    “.... Further analysis indicated that neither application of P-glycoprotein inhibitor, breast cancer resistant...”
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    Article
  13. 13
    Glesatinib, a c-MET/SMO Dual Inhibitor, Antagonizes P-glycoprotein Mediated Multidrug Resistance in Cancer Cells
    “... localization of P-gp based on Western blot and immunofluorescent analysis. Furthermore, glesatinib can...”
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    Article
  14. 14
    Esters of the Marine-Derived Triterpene Sipholenol A Reverse P-GP-Mediated Drug Resistance
    “.... In addition, western blot analysis revealed that these two compounds did not alter the expression levels of P...”
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    Article
  15. 15
    Overexpression of ABCC1 Confers Drug Resistance to Betulin
    “.... Subsequently, a high affinity score of betulin was achieved in a computational docking analysis, demonstrating...”
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    Article
  16. 16
    Establishment and Characterization of an Irinotecan-Resistant Human Colon Cancer Cell Line
    “... and cross-resistance to ABCG2 substrates in comparison with S1 cells. By Western blot analysis, S1-IR20...”
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    Article
  17. 17
    NVP-CGM097, an HDM2 Inhibitor, Antagonizes ATP-Binding Cassette Subfamily B Member 1-Mediated Drug Resistance
    “... in cancer cells. ATPase analysis showed that low concentration NVP-CGM097 activates ABCB1 ATPase activity...”
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    Article
  18. 18
    The PI3K subunits, P110α and P110β are potential targets for overcoming P-gp and BCRP-mediated MDR in cancer
    “... and BCRP in cancer cells. An ATPase assay and a structural analysis were also used to analyze the potential...”
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    Article
  19. 19
    Lamellarin O, a Pyrrole Alkaloid from an Australian Marine Sponge, Ianthella sp., Reverses BCRP Mediated Drug Resistance in Cancer Cells
    “... structure–activity relationship analysis inclusive of the natural products 1–12 and the synthetic analogues...”
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    Article
  20. 20
    MG53 suppresses tumor progression and stress granule formation by modulating G3BP2 activity in non-small cell lung cancer
    “... of MG53 and G3BP2 in human NSCLC tissues was tested by western blot analysis. The ATO-induced oxidative...”
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    Article
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