Monolayer platform using human biopsy-derived duodenal organoids for pharmaceutical research

by Tomoki Yamashita, Tatsuya Inui, Jumpei Yokota, Kentaro Kawakami, Gaku Morinaga, Masahito Takatani, Daisuke Hirayama, Ryuga Nomoto, Kohei Ito, Yunhai Cui, Stephanie Ruez, Kazuo Harada, Wataru Kishimoto, Hiroshi Nakase, Hiroyuki Mizuguchi
Published 2021-09-01

Adenovirus vector-mediated macrophage erythroblast attacher (MAEA) overexpression in primary mouse hepatocytes attenuates hepatic gluconeogenesis

by Kahori Shimizu, Minako Okamoto, Tomoyuki Terada, Fuminori Sakurai, Hiroyuki Mizuguchi, Koji Tomita, Toru Nishinaka
Published 2017-07-01

Establishment of SLC15A1/PEPT1-Knockout Human-Induced Pluripotent Stem Cell Line for Intestinal Drug Absorption Studies

by Kanae Kawai, Ryosuke Negoro, Moe Ichikawa, Tomoki Yamashita, Sayaka Deguchi, Kazuo Harada, Kazumasa Hirata, Kazuo Takayama, Hiroyuki Mizuguchi
Published 2020-06-01

miR-27b-mediated suppression of aquaporin-11 expression in hepatocytes reduces HCV genomic RNA levels but not viral titers

by Fuminori Sakurai, Rina Hashimoto, Chieko Inoue, Keisaku Wakabayashi, Tomohito Tsukamoto, Tsutomu Imaizumi, Taracena Gandara Marcos Andres, Eiko Sakai, Kanae Itsuki, Naoya Sakamoto, Takaji Wakita, Hiroyuki Mizuguchi
Published 2019-05-01

Generation of Human iPSC–Derived Intestinal Epithelial Cell Monolayers by CDX2 TransductionSummary

by Kazuo Takayama, Ryosuke Negoro, Tomoki Yamashita, Kanae Kawai, Moe Ichikawa, Takanori Mori, Noriyuki Nakatsu, Kazuo Harada, Sumito Ito, Hiroshi Yamada, Yoshiyuki Yamaura, Kazumasa Hirata, Seiichi Ishida, Hiroyuki Mizuguchi
Published 2019-01-01

Efficient Generation of Small Intestinal Epithelial-like Cells from Human iPSCs for Drug Absorption and Metabolism Studies

by Ryosuke Negoro, Kazuo Takayama, Kanae Kawai, Kazuo Harada, Fuminori Sakurai, Kazumasa Hirata, Hiroyuki Mizuguchi
Published 2018-12-01

A mammalian mirtron miR-1224 promotes tube-formation of human primary endothelial cells by targeting anti-angiogenic factor epsin2

by Eiko Sakai, Yusuke Miura, Emi Suzuki-Kouyama, Kengo Oka, Masashi Tachibana, Kenji Kawabata, Fuminori Sakurai, Hiroyuki Mizuguchi
Published 2017-07-01

Vinblastine treatment decreases the undifferentiated cell contamination of human iPSC-derived intestinal epithelial-like cells

by Moe Ichikawa, Ryosuke Negoro, Kanae Kawai, Tomoki Yamashita, Kazuo Takayama, Hiroyuki Mizuguchi
Published 2021-03-01

Suppression of Oncolytic Adenovirus-Mediated Hepatotoxicity by Liver-Specific Inhibition of NF-κB

by Mitsuhiro Machitani, Fuminori Sakurai, Keisaku Wakabayashi, Kosuke Nakatani, Masashi Tachibana, Nobuyuki Kato, Toshiyoshi Fujiwara, Hiroyuki Mizuguchi
Published 2017-12-01

Type I Interferons Impede Short Hairpin RNA-Mediated RNAi via Inhibition of Dicer-Mediated Processing to Small Interfering RNA

by Mitsuhiro Machitani, Fuminori Sakurai, Keisaku Wakabayashi, Kosuke Takayama, Masashi Tachibana, Hiroyuki Mizuguchi
Published 2017-03-01

Suppression of leaky expression of adenovirus genes by insertion of microRNA-targeted sequences in the replication-incompetent adenovirus vector genome

by Kahori Shimizu, Fuminori Sakurai, Kyoko Tomita, Yasuhito Nagamoto, Shin-ichiro Nakamura, Kazufumi Katayama, Masashi Tachibana, Kenji Kawabata, Hiroyuki Mizuguchi
Published 2014-01-01

Efficient detection of human circulating tumor cells without significant production of false-positive cells by a novel conditionally replicating adenovirus

by Fuminori Sakurai, Nobuhiro Narii, Kyoko Tomita, Shinsaku Togo, Kazuhisa Takahashi, Mitsuhiro Machitani, Masashi Tachibana, Masaaki Ouchi, Nobuyoshi Katagiri, Yasuo Urata, Toshiyoshi Fujiwara, Hiroyuki Mizuguchi
Published 2016-01-01

Generation of tetracycline-controllable CYP3A4-expressing Caco-2 cells by the piggyBac transposon system

by Moe Ichikawa, Hiroki Akamine, Michika Murata, Sumito Ito, Kazuo Takayama, Hiroyuki Mizuguchi
Published 2021-06-01

Efficient antitumor effects of a novel oncolytic adenovirus fully composed of species B adenovirus serotype 35

by Ryosuke Ono, Kosuke Takayama, Fuminori Sakurai, Hiroyuki Mizuguchi
Published 2021-03-01

Tolloid‐Like 1 Negatively Regulates Hepatic Differentiation of Human Induced Pluripotent Stem Cells Through Transforming Growth Factor Beta Signaling

by Ayumi Kiso, Yukiko Toba, Susumu Tsutsumi, Sayaka Deguchi, Keisuke Igai, Saki Koshino, Yasuhito Tanaka, Kazuo Takayama, Hiroyuki Mizuguchi
Published 2020-02-01

Evaluation of Transduction Properties of an Adenovirus Vector in Neonatal Mice

by Shunsuke Iizuka, Fuminori Sakurai, Kahori Shimizu, Kazuo Ohashi, Shin-ichiro Nakamura, Masashi Tachibana, Hiroyuki Mizuguchi
Published 2015-01-01

Proteolytic Disassembly of Viral Outer Capsid Proteins Is Crucial for Reovirus-Mediated Type-I Interferon Induction in Both Reovirus-Susceptible and Reovirus-Refractory Tumor Cells

by Yuki Katayama, Yuichi Terasawa, Masashi Tachibana, Hiroyuki Mizuguchi, Fuminori Sakurai
Published 2015-01-01

The Early Activation of CD8+ T Cells Is Dependent on Type I IFN Signaling following Intramuscular Vaccination of Adenovirus Vector

by Masahisa Hemmi, Masashi Tachibana, Sayaka Tsuzuki, Masaki Shoji, Fuminori Sakurai, Kenji Kawabata, Kouji Kobiyama, Ken J. Ishii, Shizuo Akira, Hiroyuki Mizuguchi
Published 2014-01-01

T Helper 17 Promotes Induction of Antigen-Specific Gut-Mucosal Cytotoxic T Lymphocytes following Adenovirus Vector Vaccination

by Masahisa Hemmi, Masashi Tachibana, Masashi Tachibana, Masashi Tachibana, Natsuki Fujimoto, Masaki Shoji, Fuminori Sakurai, Fuminori Sakurai, Kouji Kobiyama, Kouji Kobiyama, Ken J. Ishii, Ken J. Ishii, Shizuo Akira, Shizuo Akira, Hiroyuki Mizuguchi, Hiroyuki Mizuguchi, Hiroyuki Mizuguchi, Hiroyuki Mizuguchi
Published 2017-11-01

Neonatal Gene Therapy for Hemophilia B by a Novel Adenovirus Vector Showing Reduced Leaky Expression of Viral Genes

by Shunsuke Iizuka, Fuminori Sakurai, Masashi Tachibana, Kazuo Ohashi, Hiroyuki Mizuguchi
Published 2017-09-01