Article controlled study 200 human 164 nonhuman 142 Humans 130 metabolism 110 unclassified drug 101 male 95 female 83 enzyme linked immunosorbent assay 77 genetics 73 adult 72 protein expression 66 enzyme activity 62 Male 57 chemistry 57 human cell 57 Female 55 Animals 52 animal 52 animal experiment 51 major clinical study 48 middle aged 48 gene expression 41 Middle Aged 39 animal tissue 39 animal cell 38 animal model 38 drug effect 38 mouse 37