نتائج البحث - Beat Bornhauser

P331: THE ONCOGENIC TRANSCRIPTION FACTOR TCF3::HLF MARKS A DISTINCT ENHANCER-PROMOTER INTERACTION NETWORK IN T(17;19) POSITIVE CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA حسب Valdemar Priebe, Aneta Drakul, Stefan Zeyen, Beat Bornhauser, Raffaella Santoro, Jean-Pierre Bourquin

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Rapid Generation of Leukemogenic Chromosomal Translocations in Vivo Using CRISPR/Cas9 حسب Yun Huang, Blerim Marovca, Susanne Dettwiler, Peter Karl Bode, Beat Bornhauser, Jean-Pierre Bourquin

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MSC.sensor: Capturing cancer cell interactions with stroma for functional profiling حسب Yun Huang, Aneta Drakul, Jasmeet Sidhu, Kerstin K. Rauwolf, James Kim, Beat Bornhauser, Jean-Pierre Bourquin

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High Immunoproteasome Activity and sXBP1 in Pediatric Precursor B-ALL Predicts Sensitivity towards Proteasome Inhibitors حسب Lenka Besse, Andrej Besse, Marianne Kraus, Elmer Maurits, Herman S. Overkleeft, Beat Bornhauser, Jean-Pierre Bourquin, Christoph Driessen

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Efficient Generation of Multi-gene Knockout Cell Lines and Patient-derived Xenografts Using Multi-colored Lenti-CRISPR-Cas9 حسب Lena Behrmann, Scott McComb, Júlia Aguadé-Gorgorió, Yun Huang, Mario Hermann, Pawel Pelczar, Adriano Aguzzi, Jean Bourquin, Beat Bornhauser

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Role of stem-like cells in chemotherapy resistance and relapse in pediatric T-cell acute lymphoblastic leukemia حسب Julia Costea, Kerstin K. Rauwolf, Pietro Zafferani, Tobias Rausch, Anna Mathioudaki, Judith Zaugg, Martin Schrappe, Cornelia Eckert, Gabriele Escherich, Jean P. Bourquin, Beat Bornhauser, Andreas E. Kulozik, Jan O. Korbel

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Frequency and prognostic impact of ZEB2 H1038 and Q1072 mutations in childhood B-other acute lymphoblastic leukemia حسب Marketa Zaliova, Eliska Potuckova, Julius Lukes, Lucie Winkowska, Julia Starkova, Iveta Janotova, Lucie Sramkova, Jan Stary, Jan Zuna, Martin Stanulla, Martin Zimmermann, Beat Bornhauser, Jean-Pierre Bourquin, Cornelia Eckert, Gunnar Cario, Jan Trka

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B- and T-cell acute lymphoblastic leukemias evade chemotherapy at distinct sites in the bone marrow حسب Malwine J. Barz, Lena Behrmann, Danaëlle Capron, Gabriele Zuchtriegel, Fabio D. Steffen, Leo Kunz, Yang Zhang, Iria Jimenez Vermeerbergen, Blerim Marovca, Moritz Kirschmann, Antonia Zech, César Nombela-Arrieta, Urs Ziegler, Timm Schroeder, Beat Bornhauser, Jean-Pierre Bourquin

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SOD2 is a regulator of proteasomal degradation promoting an adaptive cellular starvation response حسب Nurul Khalida Ibrahim, Sabine Schreek, Buesra Cinar, Anna Sophie Stasche, Su Hyun Lee, Andre Zeug, Tim Dolgner, Julia Niessen, Evgeni Ponimaskin, Halyna Shcherbata, Beate Fehlhaber, Jean-Pierre Bourquin, Beat Bornhauser, Martin Stanulla, Andreas Pich, Alejandro Gutierrez, Laura Hinze

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P330: PROTEOMIC PROFILING UNCOVERS THERAPEUTIC VULNERABILITIES FOR TCF3 TRANSLOCATED B-CELL ACUTE LYMPHOBLASTIC LEUKEMIAS حسب Rebecca Hasselmann, Lena Blümel, Flavia Bernardi, Daniel Picard, Jacob Torrejon-Diaz, Vera Jepsen, Jasmin Bartl, Nan Qin, Beat Bornhauser, Sanil Bhatia, Blerim Marovca, Veronique Marsaud, Florent Dingli, Damarys Loew, Martin Stanulla, Jean-Pierre Bourquin, Arndt Borkhardt, Marc Remke, Olivier Ayrault, Ute Fischer

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Transcriptional and epigenetic rewiring by the NUP98::KDM5A fusion oncoprotein directly activates CDK12 حسب Selina Troester, Thomas Eder, Nadja Wukowits, Martin Piontek, Pablo Fernández-Pernas, Johannes Schmoellerl, Ben Haladik, Gabriele Manhart, Melanie Allram, Margarita Maurer-Granofszky, Nastassja Scheidegger, Karin Nebral, Giulio Superti-Furga, Roland Meisel, Beat Bornhauser, Peter Valent, Michael N. Dworzak, Johannes Zuber, Kaan Boztug, Florian Grebien

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Proteogenomic profiling uncovers differential therapeutic vulnerabilities between TCF3::PBX1 and TCF3::HLF translocated B-cell acute lymphoblastic leukemia حسب Lena Blumel, Flavia Bernardi, Daniel Picard, Jacob Torrejon Diaz, Vera H. Jepsen, Rebecca Hasselmann, Julian Schliehe-Diecks, Jasmin Bartl, Nan Qin, Beat Bornhauser, Sanil Bhatia, Blerim Marovka, Veronique Marsaud, Florent Dingli, Damarys Loew, Martin Stanulla, Jean-Pierre Bourqin, Arndt Borkhardt, Marc Remke, Olivier Ayrault, Ute Fischer

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PDX models recapitulate the genetic and epigenetic landscape of pediatric T‐cell leukemia حسب Paulina Richter‐Pechańska, Joachim B Kunz, Beat Bornhauser, Caroline von Knebel Doeberitz, Tobias Rausch, Büşra Erarslan‐Uysal, Yassen Assenov, Viktoras Frismantas, Blerim Marovca, Sebastian M Waszak, Martin Zimmermann, Julia Seemann, Margit Happich, Martin Stanulla, Martin Schrappe, Gunnar Cario, Gabriele Escherich, Kseniya Bakharevich, Renate Kirschner‐Schwabe, Cornelia Eckert, Martina U Muckenthaler, Jan O Korbel, Jean‐Pierre Bourquin, Andreas E Kulozik

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Chromatin accessibility landscape of pediatric T‐lymphoblastic leukemia and human T‐cell precursors حسب Büşra Erarslan‐Uysal, Joachim B Kunz, Tobias Rausch, Paulina Richter‐Pechańska, Ianthe AEM van Belzen, Viktoras Frismantas, Beat Bornhauser, Diana Ordoñez‐Rueada, Malte Paulsen, Vladimir Benes, Martin Stanulla, Martin Schrappe, Gunnar Cario, Gabriele Escherich, Kseniya Bakharevich, Renate Kirschner‐Schwabe, Cornelia Eckert, Tsvetomir Loukanov, Matthias Gorenflo, Sebastian M Waszak, Jean‐Pierre Bourquin, Martina U Muckenthaler, Jan O Korbel, Andreas E Kulozik

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The activating STAT5B N642H mutation is a common abnormality in pediatric T-cell acute lymphoblastic leukemia and confers a higher risk of relapse حسب Obul R. Bandapalli, Stephanie Schuessele, Joachim B. Kunz, Tobias Rausch, Adrian M. Stütz, Noa Tal, Ifat Geron, Nava Gershman, Shai Izraeli, Juliane Eilers, Nina Vaezipour, Renate Kirschner-Schwabe, Jana Hof, Arend von Stackelberg, Martin Schrappe, Martin Stanulla, Martin Zimmermann, Rolf Koehler, Smadar Avigad, Rupert Handgretinger, Viktoras Frismantas, Jean Pierre Bourquin, Beat Bornhauser, Jan O. Korbel, Martina U. Muckenthaler, Andreas E. Kulozik

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Pediatric ALL relapses after allo-SCT show high individuality, clonal dynamics, selective pressure, and druggable targets حسب Jessica I. Hoell, Sebastian Ginzel, Michaela Kuhlen, Andreas Kloetgen, Michael Gombert, Ute Fischer, Daniel Hein, Salih Demir, Martin Stanulla, Martin Schrappe, Udo zur Stadt, Peter Bader, Florian Babor, Friedhelm Schuster, Brigitte Strahm, Julia Alten, Anja Moericke, Gabriele Escherich, Arend von Stackelberg, Ralf Thiele, Alice C. McHardy, Christina Peters, Beat Bornhauser, Jean-Pierre Bourquin, Stefan Krause, Juergen Enczmann, Lüder Hinrich Meyer, Cornelia Eckert, Arndt Borkhardt, Roland Meisel

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Pre-clinical evaluation of second generation PIM inhibitors for the treatment of T-cell acute lymphoblastic leukemia and lymphoma حسب Renate De Smedt, Sofie Peirs, Julie Morscio, Filip Matthijssens, Juliette Roels, Lindy Reunes, Beatrice Lintermans, Steven Goossens, Tim Lammens, Nadine Van Roy, Aurore Touzart, Silvia Jenni, Yi-Chien Tsai, Federica Lovisa, Lara Mussolin, Valentina Serafin, Filip Van Nieuwerburgh, Dieter Deforce, Anne Uyttebroeck, Thomas Tousseyn, Birgit Burkhardt, Wolfram Klapper, Barbara De Moerloose, Yves Benoit, Elizabeth Macintyre, Jean-Pierre Bourquin, Giuseppe Basso, Benedetta Accordi, Beat Bornhauser, Jules Meijerink, Peter Vandenberghe, Pieter Van Vlierberghe

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A first-in-class Wiskott-Aldrich syndrome protein activator with anti-tumor activity in hematologic cancers حسب Filippo Spriano, Giulio Sartori, Jacopo Sgrignani, Laura Barnabei, Alberto J. Arribas, Matilde Guala, Ana Maria Carrasco Del Amor, Meagan R. Tomasso, Chiara Tarantelli, Luciano Cascione, Gaetanina Golino, Maria E Riveiro, Roberta Bortolozzi, Antonio Lupia, Francesco Paduano, Samuel Huguet, Keyvan Rezai, Andrea Rinaldi, Francesco Margheriti, Pedro Ventura, Greta Guarda, Giosuè Costa, Roberta Rocca, Alberto Furlan, Luuk M. Verdonk, Paolo Innocenti, Nathaniel I. Martin, Giampietro Viola, Christoph Driessen, Emanuele Zucca, Anastasios Stathis, Digvijay Gahtory, Maurits van den Nieuwboer, Beat Bornhauser, Stefano Alcaro, Francesco Trapasso, Susana Cristobal, Shae B. Padrick, Natalina Pazzi, Franco Cavalli, Andrea Cavalli, Eugenio Gaudio, Francesco Bertoni

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