Search Results - David H. Perlmutter

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  1. 1

    Mysteries of α1-antitrypsin deficiency: emerging therapeutic strategies for a challenging disease by Raafe Ghouse, Andrew Chu, Yan Wang, David H. Perlmutter

    Published in Disease Models & Mechanisms (2014-04-01)
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  2. 2

    Fluphenazine reduces proteotoxicity in C. elegans and mammalian models of alpha-1-antitrypsin deficiency. by Jie Li, Stephen C Pak, Linda P O'Reilly, Joshua A Benson, Yan Wang, Tunda Hidvegi, Pamela Hale, Christine Dippold, Michael Ewing, Gary A Silverman, David H Perlmutter

    Published in PLoS ONE (2014-01-01)
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  3. 3

    An analog of glibenclamide selectively enhances autophagic degradation of misfolded α1-antitrypsin Z. by Yan Wang, Murat C Cobanoglu, Jie Li, Tunda Hidvegi, Pamela Hale, Michael Ewing, Andrew S Chu, Zhenwei Gong, Radhika Muzumdar, Stephen C Pak, Gary A Silverman, Ivet Bahar, David H Perlmutter

    Published in PLoS ONE (2019-01-01)
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  4. 4

    A fluorescent reporter for rapid assessment of autophagic flux reveals unique autophagy signatures during C. elegans post-embryonic development and identifies compounds that modula... by Zachary D. Dawson, Hemalatha Sundaramoorthi, Suk Regmi, Bo Zhang, Stephanie Morrison, Sara M. Fielder, Jessie R. Zhang, Hieu Hoang, David H. Perlmutter, Cliff J. Luke, Gary A. Silverman, Stephen C. Pak

    Published in Autophagy Reports (2024-12-01)
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  5. 5

    A pathogenic Tau mutation drives autophagy-lysosome dysfunction that limits Tau degradation in a model of frontotemporal dementia by Farzaneh S. Mirfakhar, Jacob A. Marsh, Chihiro Sato, Kylie J. Schache, Miguel A. Minaya, Roland E. Dolle, Stephen C. Pak, Gary A. Silverman, David H. Perlmutter, Shannon L. Macauley, Celeste M. Karch

    Published in Nature Communications (2026-03-01)
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  6. 6

    Resolution of hepatic fibrosis after ZFN-mediated gene editing in the PiZ mouse model of human α1-antitrypsin deficiency by Yanfeng Li, Chandan Guha, Patrik Asp, Xia Wang, Tatyana L. Tchaikovskya, Kenneth Kim, Matthew Mendel, Gregory J. Cost, David H. Perlmutter, Namita Roy-Chowdhury, Ira J. Fox, Anthony Conway, Jayanta Roy-Chowdhury

    Published in Hepatology Communications (2023-03-01)
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  7. 7

    Multiple Genes Core to ERAD, Macroautophagy and Lysosomal Degradation Pathways Participate in the Proteostasis Response in α1-Antitrypsin DeficiencySummary by Jie Li, Francesca Moretti, Tunda Hidvegi, Sanja Sviben, James A.J. Fitzpatrick, Hemalatha Sundaramoorthi, Stephen C. Pak, Gary A. Silverman, Britta Knapp, Ireos Filipuzzi, John Alford, John Reece-Hoyes, Florian Nigsch, Leon O. Murphy, Beat Nyfeler, David H. Perlmutter

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