Search Results - Donald E. Ingber
Donald E. Ingber
Donald E. Ingber (born 1956) is an American cell biologist and bioengineer. He is the founding director of the Wyss Institute for Biologically Inspired Engineering at Harvard University, the ''Judah Folkman Professor of Vascular Biology'' at Harvard Medical School and Boston Children's Hospital, and Professor of Bioengineering at the Harvard John A. Paulson School of Engineering and Applied Sciences. He is also a member of the American Institute for Medical and Biological Engineering, the National Academy of Engineering, the National Academy of Medicine, the National Academy of Inventors, and the American Academy of Arts and Sciences.Ingber is a founder of the emerging fields of biologically inspired engineering. He has made pioneering contributions to numerous other disciplines including mechanobiology, cytoskeletal biology, extracellular matrix biology, integrin signaling, tumor angiogenesis, tissue engineering, nanobiotechnology, systems biology, and translational medicine. Ingber has authored more than 470 publications in scientific journals and books, and is an inventor on more than 190 patents spanning anti-cancer therapeutics, tissue engineering, medical devices, drug delivery systems, biomimetic materials, nanotherapeutics, and bioinformatics software.
Ingber has been scientific founder of five companies: Neomorphics, Inc., a tissue engineering startup which led to clinical products through subsequent acquisitions (Advanced Tissue Sciences Inc.); Tensegra, Inc. (formerly known as Molecular Geodesics, Inc.,) which 3D-printed medical devices; and most recently, Emulate, Inc., which formed to commercialize human "organs-on-chips" that accelerate drug development, detect toxicities and advance personalized medicine by replacing animal testing; Boa Biomedical, Inc. (originally known as Opsonix, Inc.), which aims to reduce deaths due to sepsis and blood infections by removing pathogens from the blood; and FreeFlow Medical Devices, LLC, which develops special coatings for medical devices to eliminate the formation of blood clots and biofilms on materials. Provided by Wikipedia
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Broad-spectrum coronavirus inhibitors discovered by modeling viral fusion dynamics by Charles B. Reilly, Joel Moore, Shanda Lightbown, Austin Paul, Sylvie G. Bernier, Kenneth E. Carlson, Donald E. Ingber, Donald E. Ingber, Donald E. Ingber
Published in Frontiers in Molecular Biosciences (2025-05-01)Get full text
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Dietary flavonoids form supramolecular assemblies, alter biochemistry, and enhance cell resilience by Charles B. Reilly, Sylvie G. Bernier, Sanjid Shahriar, Viktor Horvath, Michael Lewandowski, Emilia Javorsky, Bogdan Budnik, Donald E. Ingber, Donald E. Ingber, Donald E. Ingber
Published in Frontiers in Nutrition (2025-09-01)Get full text
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Harnessing Colon Chip Technology to Identify Commensal Bacteria That Promote Host Tolerance to Infection by Francesca S. Gazzaniga, Francesca S. Gazzaniga, Diogo M. Camacho, Meng Wu, Matheus F. Silva Palazzo, Alexandre L. M. Dinis, Francis N. Grafton, Mark J. Cartwright, Michael Super, Dennis L. Kasper, Donald E. Ingber, Donald E. Ingber, Donald E. Ingber
Published in Frontiers in Cellular and Infection Microbiology (2021-03-01)Get full text
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Direct therapeutic effect of sulfadoxine-pyrimethamine on nutritional deficiency-induced enteric dysfunction in a human Intestine ChipResearch in context by Seongmin Kim, Arash Naziripour, Pranav Prabhala, Viktor Horváth, Abidemi Junaid, David T. Breault, Girija Goyal, Donald E. Ingber
Published in EBioMedicine (2024-01-01)Get full text
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Redox-Modified Nanostructured Electrochemical Surfaces for Continuous Glucose Monitoring in Complex Biological Fluids by Sajjad Janfaza, Nandhinee Radha Shanmugam, Pawan Jolly, Prashanthi Kovur, Upasana Singh, Scott Mackay, David Wishart, Donald E. Ingber
Published in Nanomaterials (2024-05-01)Get full text
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A human lung alveolus-on-a-chip model of acute radiation-induced lung injury by Queeny Dasgupta, Amanda Jiang, Amy M. Wen, Robert J. Mannix, Yuncheng Man, Sean Hall, Emilia Javorsky, Donald E. Ingber
Published in Nature Communications (2023-10-01)Get full text
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Cervical mucus in linked human Cervix and Vagina Chips modulates vaginal dysbiosis by Ola Gutzeit, Aakanksha Gulati, Zohreh Izadifar, Anna Stejskalova, Hassan Rhbiny, Justin Cotton, Bogdan Budnik, Sanjid Shahriar, Girija Goyal, Abidemi Junaid, Donald E. Ingber
Published in npj Women's Health (2025-01-01)Get full text
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MRC1 and LYVE1 expressing macrophages in vascular beds of GNAQ p.R183Q driven capillary malformations in Sturge Weber syndrome by Sana Nasim, Colette Bichsel, Stephen Dayneka, Robert Mannix, Annegret Holm, Mathew Vivero, Sanda Alexandrescu, Anna Pinto, Arin K. Greene, Donald E. Ingber, Joyce Bischoff
Published in Acta Neuropathologica Communications (2024-03-01)Get full text
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Patient-derived esophageal adenocarcinoma organ chip: a physiologically relevant platform for functional precision oncology by Sanjima Pal, Elee Shimshoni, Salvador Flores Torres, Mingyang Kong, Kulsum Tai, Veena Sangwan, Nicholas Bertos, Swneke Donovan Bailey, Julie Bérubé, Donald E. Ingber, Lorenzo Ferri
Published in Journal of Translational Medicine (2025-05-01)Get full text
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Human Gut-On-A-Chip Supports Polarized Infection of Coxsackie B1 Virus In Vitro. by Remi Villenave, Samantha Q Wales, Tiama Hamkins-Indik, Efstathia Papafragkou, James C Weaver, Thomas C Ferrante, Anthony Bahinski, Christopher A Elkins, Michael Kulka, Donald E Ingber
Published in PLoS ONE (2017-01-01)Get full text
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An Antimicrobial and Antifibrotic Coating for Implantable Biosensors by Sofia Wareham-Mathiassen, Pawan Jolly, Nandhinee Radha Shanmugam, Badrinath Jagannath, Pranav Prabhala, Yunhao Zhai, Alican Ozkan, Arash Naziripour, Rohini Singh, Henrik Bengtsson, Thomas Bjarnsholt, Donald E. Ingber
Published in Biosensors (2025-03-01)Get full text
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Enhancers of Host Immune Tolerance to Bacterial Infection Discovered Using Linked Computational and Experimental Approaches by Megan M. Sperry, Richard Novak, Vishal Keshari, Alexandre L. M. Dinis, Mark J. Cartwright, Diogo M. Camacho, Jean‐François Paré, Michael Super, Michael Levin, Donald E. Ingber
Published in Advanced Science (2022-09-01)Get full text
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Micrometer-thick and porous nanocomposite coating for electrochemical sensors with exceptional antifouling and electroconducting properties by Jeong-Chan Lee, Su Yeong Kim, Jayeon Song, Hyowon Jang, Min Kim, Hanul Kim, Siyoung Q. Choi, Sunjoo Kim, Pawan Jolly, Taejoon Kang, Steve Park, Donald E. Ingber
Published in Nature Communications (2024-02-01)Get full text
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Purified and Recombinant Hemopexin: Protease Activity and Effect on Neutrophil Chemotaxis by Tian Lin, Jialin Liu, Feng Huang, Tjitske S R van Engelen, Sujatha R Thundivalappil, Frank E Riley, Michael Super, Alexander L Watters, Ann Smith, Nathan Brinkman, Donald E Ingber, H Shaw Warren
Published in Molecular Medicine (2016-01-01)Get full text
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AAV-mediated gene therapy targeting TRPV4 mechanotransduction for inhibition of pulmonary vascular leakage by Juan Li, Amy M. Wen, Ratnakar Potla, Ezekiel Benshirim, Ariel Seebarran, Maximilian A. Benz, Olivier Y. F. Henry, Benjamin D. Matthews, Rachelle Prantil-Baun, Sarah E. Gilpin, Oren Levy, Donald E. Ingber
Published in APL Bioengineering (2019-12-01)Get full text
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Mechanical control of innate immune responses against viral infection revealed in a human lung alveolus chip by Haiqing Bai, Longlong Si, Amanda Jiang, Chaitra Belgur, Yunhao Zhai, Roberto Plebani, Crystal Yuri Oh, Melissa Rodas, Aditya Patil, Atiq Nurani, Sarah E. Gilpin, Rani K. Powers, Girija Goyal, Rachelle Prantil-Baun, Donald E. Ingber
Published in Nature Communications (2022-04-01)Get full text
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