Search Results - John G. Doench

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  1. 1

    Natural variation in a single amino acid substitution underlies physiological responses to topoisomerase II poisons. by Stefan Zdraljevic, Christine Strand, Hannah S Seidel, Daniel E Cook, John G Doench, Erik C Andersen

    Published in PLoS Genetics (2017-07-01)
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  2. 2

    Accounting for small variations in the tracrRNA sequence improves sgRNA activity predictions for CRISPR screening by Peter C. DeWeirdt, Abby V. McGee, Fengyi Zheng, Ifunanya Nwolah, Mudra Hegde, John G. Doench

    Published in Nature Communications (2022-09-01)
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  3. 3

    Morphological Profiles of RNAi-Induced Gene Knockdown Are Highly Reproducible but Dominated by Seed Effects. by Shantanu Singh, Xiaoyun Wu, Vebjorn Ljosa, Mark-Anthony Bray, Federica Piccioni, David E Root, John G Doench, Jesse S Boehm, Anne E Carpenter

    Published in PLoS ONE (2015-01-01)
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  4. 4

    A FACS-Based Genome-wide CRISPR Screen Reveals a Requirement for COPI in Chlamydia trachomatis Invasion by Joseph S. Park, Jennifer D. Helble, Jacob E. Lazarus, Guanhua Yang, Carlos J. Blondel, John G. Doench, Michael N. Starnbach, Matthew K. Waldor

    Published in iScience (2019-01-01)
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  5. 5

    Protocol for in vivo CRISPR screening using selective CRISPR antigen removal lentiviral vectors by Sarah Kate Lane-Reticker, Emily A. Kessler, Audrey J. Muscato, Sarah Y. Kim, John G. Doench, Kathleen B. Yates, Robert T. Manguso, Juan Dubrot

    Published in STAR Protocols (2023-03-01)
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  6. 6

    Targeted shRNA screening identified critical roles of pleckstrin-2 in erythropoiesis by Baobing Zhao, Ganesan Keerthivasan, Yang Mei, Jing Yang, James McElherne, Piu Wong, John G. Doench, Gang Feng, David E. Root, Peng Ji

    Published in Haematologica (2014-07-01)
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  7. 7

    Efficient gene knockout and genetic interaction screening using the in4mer CRISPR/Cas12a multiplex knockout platform by Nazanin Esmaeili Anvar, Chenchu Lin, Xingdi Ma, Lori L. Wilson, Ryan Steger, Annabel K. Sangree, Medina Colic, Sidney H. Wang, John G. Doench, Traver Hart

    Published in Nature Communications (2024-04-01)
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  8. 8

    Developing SHP2-based combination therapy for KRAS-amplified cancer by Tianxia Li, Osamu Kikuchi, Jin Zhou, Yichen Wang, Babita Pokharel, Klavdija Bastl, Prafulla Gokhale, Aine Knott, Yanxi Zhang, John G. Doench, Zandra V. Ho, Daniel V.T. Catenacci, Adam J. Bass

    Published in JCI Insight (2023-02-01)
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  9. 9

    Host cell CRISPR genomics and modelling reveal shared metabolic vulnerabilities in the intracellular development of Plasmodium falciparum and related hemoparasites by Marina Maurizio, Maria Masid, Kerry Woods, Reto Caldelari, John G. Doench, Arunasalam Naguleswaran, Denis Joly, Martín González-Fernández, Jonas Zemp, Mélanie Borteele, Vassily Hatzimanikatis, Volker Heussler, Sven Rottenberg, Philipp Olias

    Published in Nature Communications (2024-07-01)
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  10. 10

    A genetic screen identifies a protective type III interferon response to Cryptosporidium that requires TLR3 dependent recognition. by Alexis R Gibson, Adam Sateriale, Jennifer E Dumaine, Julie B Engiles, Ryan D Pardy, Jodi A Gullicksrud, Keenan M O'Dea, John G Doench, Daniel P Beiting, Christopher A Hunter, Boris Striepen

    Published in PLoS Pathogens (2022-05-01)
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  11. 11

    Chromatin complex dependencies reveal targeting opportunities in leukemia by Fadi J. Najm, Peter DeWeirdt, Molly M. Moore, Samantha M. Bevill, Chadi A. El Farran, Kevin A. Macias, Mudra Hegde, Amanda L. Waterbury, Brian B. Liau, Peter van Galen, John G. Doench, Bradley E. Bernstein

    Published in Nature Communications (2023-01-01)
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  12. 12

    Multi-locus CRISPRi targeting with a single truncated guide RNA by Molly M. Moore, Siddarth Wekhande, Robbyn Issner, Alejandro Collins, Anna J. Cruz, Yanjing V. Liu, Nauman Javed, Salvador Casaní-Galdón, Jason D. Buenrostro, Charles B. Epstein, Eugenio Mattei, John G. Doench, Bradley E. Bernstein, Noam Shoresh, Fadi J. Najm

    Published in Nature Communications (2025-02-01)
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  13. 13

    Germline variation contributes to false negatives in CRISPR-based experiments with varying burden across ancestries by Sean A. Misek, Aaron Fultineer, Jeremie Kalfon, Javad Noorbakhsh, Isabella Boyle, Priyanka Roy, Joshua Dempster, Lia Petronio, Katherine Huang, Alham Saadat, Thomas Green, Adam Brown, John G. Doench, David E. Root, James M. McFarland, Rameen Beroukhim, Jesse S. Boehm

    Published in Nature Communications (2024-06-01)
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  14. 14

    Regulation of neuroendocrine plasticity by the RNA-binding protein ZFP36L1 by Hsiao-Yun Chen, Yavuz T. Durmaz, Yixiang Li, Amin H. Sabet, Amir Vajdi, Thomas Denize, Emily Walton, Yasmin Nabil Laimon, John G. Doench, Navin R. Mahadevan, Julie-Aurore Losman, David A. Barbie, Michael Y. Tolstorukov, Charles M. Rudin, Triparna Sen, Sabina Signoretti, Matthew G. Oser

    Published in Nature Communications (2022-08-01)
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  15. 15

    PI3K activation allows immune evasion by promoting an inhibitory myeloid tumor microenvironment by Yashaswi Shrestha, Michael Quigley, Travis Hughes, Robert T Manguso, Natalie B Collins, Rose Al Abosy, Brian C Miller, Kevin Bi, Qihong Zhao, Jeffrey J Ishizuka, Kathleen B Yates, Hans W Pope, Marc Wadsworth, Alex K Shalek, Jesse S Boehm, William C Hahn, John G Doench, W Nicholas Haining

    Published in Journal for ImmunoTherapy of Cancer (2022-03-01)
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  16. 16

    Synergistic interactions with PI3K inhibition that induce apoptosis by Yaara Zwang, Oliver Jonas, Casandra Chen, Mikael L Rinne, John G Doench, Federica Piccioni, Li Tan, Hai-Tsang Huang, Jinhua Wang, Young Jin Ham, Joyce O'Connell, Patrick Bhola, Mihir Doshi, Matthew Whitman, Michael Cima, Anthony Letai, David E Root, Robert S Langer, Nathanael Gray, William C Hahn

    Published in eLife (2017-05-01)
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  17. 17

    An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer by Ji Li, Peter S Choi, Christine L Chaffer, Katherine Labella, Justin H Hwang, Andrew O Giacomelli, Jong Wook Kim, Nina Ilic, John G Doench, Seav Huong Ly, Chao Dai, Kimberly Hagel, Andrew L Hong, Ole Gjoerup, Shom Goel, Jennifer Y Ge, David E Root, Jean J Zhao, Angela N Brooks, Robert A Weinberg, William C Hahn

    Published in eLife (2018-07-01)
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  18. 18

    DYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent manner. by Madison S Strine, Wesley L Cai, Jin Wei, Mia Madel Alfajaro, Renata B Filler, Scott B Biering, Sylvia Sarnik, Ryan D Chow, Ajinkya Patil, Kasey S Cervantes, Clayton K Collings, Peter C DeWeirdt, Ruth E Hanna, Kevin Schofield, Christopher Hulme, Silvana Konermann, John G Doench, Patrick D Hsu, Cigall Kadoch, Qin Yan, Craig B Wilen

    Published in PLoS Biology (2023-06-01)
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  19. 19

    Leukemia-intrinsic determinants of CAR-T response revealed by iterative in vivo genome-wide CRISPR screening by Azucena Ramos, Catherine E. Koch, Yunpeng Liu-Lupo, Riley D. Hellinger, Taeyoon Kyung, Keene L. Abbott, Julia Fröse, Daniel Goulet, Khloe S. Gordon, Keith P. Eidell, Paul Leclerc, Charles A. Whittaker, Rebecca C. Larson, Audrey J. Muscato, Kathleen B. Yates, Juan Dubrot, John G. Doench, Aviv Regev, Matthew G. Vander Heiden, Marcela V. Maus, Robert T. Manguso, Michael E. Birnbaum, Michael T. Hemann

    Published in Nature Communications (2023-12-01)
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  20. 20

    KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer by Elsa B Krall, Belinda Wang, Diana M Munoz, Nina Ilic, Srivatsan Raghavan, Matthew J Niederst, Kristine Yu, David A Ruddy, Andrew J Aguirre, Jong Wook Kim, Amanda J Redig, Justin F Gainor, Juliet A Williams, John M Asara, John G Doench, Pasi A Janne, Alice T Shaw, Robert E McDonald III, Jeffrey A Engelman, Frank Stegmeier, Michael R Schlabach, William C Hahn

    Published in eLife (2017-02-01)
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