Search Results - L Wiggs

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  1. 1

    Metabolomic Signatures and Predictive Utility of <i>LOXL1</i>-Associated Genetic Risk Scores for Exfoliation Syndrome/Glaucoma in US Cohorts by Namuunaa Juramt, Oana A. Zeleznik, Louis R. Pasquale, Janey L. Wiggs, Jae H. Kang

    Published in Metabolites (2025-08-01)
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  2. 2

    Interaction of background genetic risk, psychotropic medications, and primary angle closure glaucoma in the UK Biobank. by Sayuri Sekimitsu, Jiali Wang, Tobias Elze, Ayellet V Segrè, Janey L Wiggs, Nazlee Zebardast

    Published in PLoS ONE (2022-01-01)
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  3. 3

    Bupropion use and risk of open-angle glaucoma among enrollees in a large U.S. managed care network. by Joshua D Stein, Nidhi Talwar, Jae H Kang, Olivia I Okereke, Janey L Wiggs, Louis R Pasquale

    Published in PLoS ONE (2015-01-01)
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  4. 4

    The use of MElatonin in children with Neurodevelopmental Disorders and impaired Sleep: a randomised, double-blind, placebo-controlled, parallel study (MENDS) by RE Appleton, AP Jones, C Gamble, PR Williamson, L Wiggs, P Montgomery, A Sutcliffe, C Barker, P Gringras

    Published in Health Technology Assessment (2012-10-01)
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  5. 5

    Mechanosensitive ion channel gene survey suggests potential roles in primary open angle glaucoma by Wendy W. Liu, Tyler G. Kinzy, Jessica N. Cooke Bailey, Zihe Xu, Pirro Hysi, Janey L. Wiggs, NEIGHBORHOOD Consortium

    Published in Scientific Reports (2023-09-01)
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  6. 6

    Association between Diabetes and Exfoliation Syndrome by Megan Yu, BS, Hannah H. Hwang, BS, Janey L. Wiggs, MD, PhD, Louis R. Pasquale, MD, Jae H. Kang, ScD

    Published in Ophthalmology Science (2024-05-01)
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  7. 7

    POU6F2, a risk factor for glaucoma, myopia and dyslexia, labels specific populations of retinal ganglion cells by Fangyu Lin, Ying Li, Jiaxing Wang, Sandra Jardines, Rebecca King, Micah A. Chrenek, Janey L. Wiggs, Jeffrey H. Boatright, Eldon E. Geisert

    Published in Scientific Reports (2024-05-01)
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  8. 8

    Identification of blood-derived DNA methylation biomarkers of glaucoma and intraocular pressure measurements in three European ancestry cohorts including the Canadian longitudinal... by Xiaofan Jiang, Omar A. Mahroo, Anthony P Khawaja, Dorota Skowronska-Krawczyk, David A. Mackey, Janey L. Wiggs, Christopher J. Hammond, Pirro G. Hysi, Christopher G. Bell

    Published in Epigenetics (2025-12-01)
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  9. 9

    Prediagnostic Plasma Metabolomic Profiles Using NMR for Exfoliation Glaucoma Among US Health Professionals by Akiko Hanyuda, Oana A. Zeleznik, Yoshihiko Raita, Danielle E. Haslam, Qi Sun, Kazuno Negishi, Louis R. Pasquale, Jessica Lasky-Su, Janey L. Wiggs, Jae H. Kang

    Published in Metabolites (2025-07-01)
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  10. 10

    Thrombospondin 1 missense alleles induce extracellular matrix protein aggregation and TM dysfunction in congenital glaucoma by Haojie Fu, Owen M. Siggs, Lachlan S.W. Knight, Sandra E. Staffieri, Jonathan B. Ruddle, Amy E. Birsner, Edward Ryan Collantes, Jamie E. Craig, Janey L. Wiggs, Robert J. D’Amato

    Published in The Journal of Clinical Investigation (2022-12-01)
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  11. 11

    Machine Learning on Prediagnostic Metabolite Data Identifies Etiologic Endotypes of Exfoliation Glaucoma in United States Health Professionals by Akiko Hanyuda, MD, MPH, Oana A. Zeleznik, PhD, Yoshihiko Raita, MD, MPH, Kazuno Negishi, MD, PhD, Louis R. Pasquale, MD, Jessica Lasky-Su, ScD, Janey L. Wiggs, MD, PhD, Jae H. Kang, ScD

    Published in Ophthalmology Science (2025-05-01)
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  12. 12

    Disentangling the genetic overlap and causal relationships between primary open-angle glaucoma, brain morphology and four major neurodegenerative disordersResearch in context by Santiago Diaz-Torres, Weixiong He, Jackson Thorp, Sahba Seddighi, Sean Mullany, Christopher J. Hammond, Pirro G. Hysi, Louis R. Pasquale, Anthony P. Khawaja, Alex W. Hewitt, Jamie E. Craig, David A. Mackey, Janey L. Wiggs, Cornelia van Duijn, Michelle K. Lupton, Jue-Sheng Ong, Stuart MacGregor, Puya Gharahkhani

    Published in EBioMedicine (2023-06-01)
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  13. 13

    Pyruvate and related energetic metabolites modulate resilience against high genetic risk for glaucoma by Keva Li, Nicholas Tolman, Ayellet V Segrè, Kelsey V Stuart, Oana A Zeleznik, Neeru A Vallabh, Kuang Hu, Nazlee Zebardast, Akiko Hanyuda, Yoshihiko Raita, Christa Montgomery, Chi Zhang, Pirro G Hysi, Ron Do, Anthony P Khawaja, Janey L Wiggs, Jae H Kang, Simon WM John, Louis R Pasquale, UK Biobank Eye and Vision Consortium

    Published in eLife (2025-04-01)
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  14. 14

    Genome-wide meta-analysis identifies 22 loci for normal tension glaucoma with significant overlap with high tension glaucoma by Santiago Diaz-Torres, Weixiong He, Regina Yu, IGGC International Glaucoma Genetics Consortium, Anthony P. Khawaja, Christopher J. Hammond, Pirro G. Hysi, Louis R. Pasquale, Yeda Wu, Michiaki Kubo, Masato Akiyama, Tin Aung, Ching-Yu Cheng, Chiea Chuen Khor, Peter Kraft, Jae H. Kang, Alex W. Hewitt, David A. Mackey, Jamie E. Craig, Janey L. Wiggs, Jue-Sheng Ong, Stuart MacGregor, Puya Gharahkhani

    Published in Nature Communications (2024-11-01)
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  15. 15

    Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma by Andrew R. Hamel, Wenjun Yan, John M. Rouhana, Aboozar Monovarfeshani, Xinyi Jiang, Puja A. Mehta, Jayshree Advani, Yuyang Luo, Qingnan Liang, Skanda Rajasundaram, Arushi Shrivastava, Katherine Duchinski, Sreekar Mantena, Jiali Wang, Tavé van Zyl, Louis R. Pasquale, Anand Swaroop, Puya Gharahkhani, Anthony P. Khawaja, Stuart MacGregor, International Glaucoma Genetics Consortium (IGGC), Rui Chen, Veronique Vitart, Joshua R. Sanes, Janey L. Wiggs, Ayellet V. Segrè

    Published in Nature Communications (2024-01-01)
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  16. 16

    Correction: Genetic variation affects morphological retinal phenotypes extracted from UK Biobank optical coherence tomography images. by Hannah Currant, Pirro Hysi, Tomas W Fitzgerald, Puya Gharahkhani, Pieter W M Bonnemaijer, Anne Senabouth, Alex W Hewitt, UK Biobank Eye and Vision Consortium, International Glaucoma Genetics Consortium, Denize Atan, Tin Aung, Jason Charng, Hélène Choquet, Jamie Craig, Peng T Khaw, Caroline C W Klaver, Michiaki Kubo, Jue-Sheng Ong, Louis R Pasquale, Charles A Reisman, Maciej Daniszewski, Joseph E Powell, Alice Pébay, Mark J Simcoe, Alberta A H J Thiadens, Cornelia M van Duijn, Seyhan Yazar, Eric Jorgenson, Stuart MacGregor, Chris J Hammond, David A Mackey, Janey L Wiggs, Paul J Foster, Praveen J Patel, Ewan Birney, Anthony P Khawaja

    Published in PLoS Genetics (2021-10-01)
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  17. 17

    Genetic variation affects morphological retinal phenotypes extracted from UK Biobank optical coherence tomography images. by Hannah Currant, Pirro Hysi, Tomas W Fitzgerald, Puya Gharahkhani, Pieter W M Bonnemaijer, Anne Senabouth, Alex W Hewitt, UK Biobank Eye and Vision Consortium, International Glaucoma Genetics Consortium, Denize Atan, Tin Aung, Jason Charng, Hélène Choquet, Jamie Craig, Peng T Khaw, Caroline C W Klaver, Michiaki Kubo, Jue-Sheng Ong, Louis R Pasquale, Charles A Reisman, Maciej Daniszewski, Joseph E Powell, Alice Pébay, Mark J Simcoe, Alberta A H J Thiadens, Cornelia M van Duijn, Seyhan Yazar, Eric Jorgenson, Stuart MacGregor, Chris J Hammond, David A Mackey, Janey L Wiggs, Paul J Foster, Praveen J Patel, Ewan Birney, Anthony P Khawaja

    Published in PLoS Genetics (2021-05-01)
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  18. 18

    Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma. by Janey L Wiggs, Brian L Yaspan, Michael A Hauser, Jae H Kang, R Rand Allingham, Lana M Olson, Wael Abdrabou, Bao J Fan, Dan Y Wang, Wendy Brodeur, Donald L Budenz, Joseph Caprioli, Andrew Crenshaw, Kristy Crooks, Elizabeth Delbono, Kimberly F Doheny, David S Friedman, Douglas Gaasterland, Terry Gaasterland, Cathy Laurie, Richard K Lee, Paul R Lichter, Stephanie Loomis, Yutao Liu, Felipe A Medeiros, Cathy McCarty, Daniel Mirel, Sayoko E Moroi, David C Musch, Anthony Realini, Frank W Rozsa, Joel S Schuman, Kathleen Scott, Kuldev Singh, Joshua D Stein, Edward H Trager, Paul Vanveldhuisen, Douglas Vollrath, Gadi Wollstein, Sachiko Yoneyama, Kang Zhang, Robert N Weinreb, Jason Ernst, Manolis Kellis, Tomohiro Masuda, Don Zack, Julia E Richards, Margaret Pericak-Vance, Louis R Pasquale, Jonathan L Haines

    Published in PLoS Genetics (2012-01-01)
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