Search Results - Manfred Jücker
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Dual Targeting of Akt and mTORC1 Impairs Repair of DNA Double-Strand Breaks and Increases Radiation Sensitivity of Human Tumor Cells. by Marina Holler, Astrid Grottke, Katharina Mueck, Julia Manes, Manfred Jücker, H Peter Rodemann, Mahmoud Toulany
Published in PLoS ONE (2016-01-01)Get full text
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High Sensitivity of Circulating Tumor Cells Derived from a Colorectal Cancer Patient for Dual Inhibition with AKT and mTOR Inhibitors by Daniel J. Smit, Laure Cayrefourcq, Marie-Therese Haider, Nico Hinz, Klaus Pantel, Catherine Alix-Panabières, Manfred Jücker
Published in Cells (2020-09-01)Get full text
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Analysis of the Plasticity of Circulating Tumor Cells Reveals Differentially Regulated Kinases During the Suspension‐to‐Adherent Transition by Daniel J. Smit, Konstantin Hoffer, Bettina Bettin, Malte Kriegs, Laure Cayrefourcq, Udo Schumacher, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker
Published in Cancer Medicine (2024-10-01)Get full text
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SHIP1 Is Present but Strongly Downregulated in T-ALL, and after Restoration Suppresses Leukemia Growth in a T-ALL Xenotransplantation Mouse Model by Patrick Ehm, Ruth Rietow, Wiebke Wegner, Lara Bußmann, Malte Kriegs, Kevin Dierck, Stefan Horn, Thomas Streichert, Martin Horstmann, Manfred Jücker
Published in Cells (2023-07-01)Get full text
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Ectopic Expression of Hematopoietic SHIP1 in Human Colorectal Cancer by Matthias Schaks, Kristina Allgoewer, Nina Nelson, Patrick Ehm, Asmus Heumann, Florian Ewald, Udo Schumacher, Ronald Simon, Guido Sauter, Manfred Jücker
Published in Biomedicines (2020-07-01)Get full text
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Knockdown of AKT3 Activates HER2 and DDR Kinases in Bone-Seeking Breast Cancer Cells, Promotes Metastasis In Vivo and Attenuates the TGFβ/CTGF Axis by Nico Hinz, Anke Baranowsky, Michael Horn, Malte Kriegs, Freya Sibbertsen, Daniel J. Smit, Philippe Clezardin, Tobias Lange, Thorsten Schinke, Manfred Jücker
Published in Cells (2021-02-01)Get full text
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Ikaros sets the threshold for negative B-cell selection by regulation of the signaling strength of the AKT pathway by Patrick A. H. Ehm, Stefan Horn, Konstantin Hoffer, Malte Kriegs, Michael Horn, Susanne Giehler, Marcus Nalaskowski, Christoph Rehbach, Martin A. Horstmann, Manfred Jücker
Published in Cell Communication and Signaling (2024-07-01)Get full text
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Generating Patient-Derived HCC Cell Lines Suitable for Predictive In Vitro and In Vivo Drug Screening by Orthotopic Transplantation by Lisa Staffeldt, Gregor Mattert, Kristoffer Riecken, Götz Rövenstrunk, Anika Volkmar, Asmus Heumann, Mohamed Moustafa, Manfred Jücker, Boris Fehse, Udo Schumacher, Stefan Lüth, Janine Kah
Published in Cells (2023-12-01)Get full text
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K-Ras(V12) differentially affects the three Akt isoforms in lung and pancreatic carcinoma cells and upregulates E-cadherin and NCAM via Akt3 by Rebekka Geißert, Angela Lammert, Stefanie Wirth, Rabea Hönig, Dirk Lohfink, Monika Unger, Denis Pek, Konstantin Schlüter, Theresa Scheftschik, Daniel J. Smit, Manfred Jücker, Andre Menke, Klaudia Giehl
Published in Cell Communication and Signaling (2024-01-01)Get full text
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Activation of CD44/PAK1/AKT signaling promotes resistance to FGFR1 inhibition in squamous-cell lung cancer by Omar Elakad, Björn Häupl, Vera Labitzky, Sha Yao, Stefan Küffer, Alexander von Hammerstein-Equord, Bernhard C. Danner, Manfred Jücker, Henning Urlaub, Tobias Lange, Philipp Ströbel, Thomas Oellerich, Hanibal Bohnenberger
Published in npj Precision Oncology (2022-07-01)Get full text
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Functional Role of Fatty Acid Synthase for Signal Transduction in Core-Binding Factor Acute Myeloid Leukemia with an Activating c-Kit Mutation by Ruimeng Zhuang, Bente Siebels, Konstantin Hoffer, Anna Worthmann, Stefan Horn, Nikolas Christian Cornelius von Bubnoff, Cyrus Khandanpour, Niklas Gebauer, Sivahari Prasad Gorantla, Hanna Voss, Hartmut Schlüter, Malte Kriegs, Walter Fiedler, Carsten Bokemeyer, Manfred Jücker, Maxim Kebenko
Published in Biomedicines (2025-03-01)Get full text
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Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model by Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker
Published in Molecular Oncology (2025-10-01)Get full text
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Tumor cell integrin β4 and tumor stroma E-/P-selectin cooperatively regulate tumor growth in vivo by Sandra Genduso, Vera Freytag, Daniela Schetler, Lennart Kirchner, Alina Schiecke, Hanna Maar, Daniel Wicklein, Florian Gebauer, Katharina Bröker, Christine Stürken, Karin Milde-Langosch, Leticia Oliveira-Ferrer, Franz L. Ricklefs, Florian Ewald, Gerrit Wolters-Eisfeld, Kristoffer Riecken, Ludmilla Unrau, Linda Krause, Hanibal Bohnenberger, Anne Offermann, Sven Perner, Susanne Sebens, Katrin Lamszus, Linda Diehl, Stefan Linder, Manfred Jücker, Udo Schumacher, Tobias Lange
Published in Journal of Hematology & Oncology (2023-03-01)Get full text
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Characterization of circulating breast cancer cells with tumorigenic and metastatic capacity by Claudia Koch, Andra Kuske, Simon A Joosse, Gökhan Yigit, George Sflomos, Sonja Thaler, Daniel J Smit, Stefan Werner, Kerstin Borgmann, Sebastian Gärtner, Parinaz Mossahebi Mohammadi, Laura Battista, Laure Cayrefourcq, Janine Altmüller, Gabriela Salinas‐Riester, Kaamini Raithatha, Arne Zibat, Yvonne Goy, Leonie Ott, Kai Bartkowiak, Tuan Zea Tan, Qing Zhou, Michael R Speicher, Volkmar Müller, Tobias M Gorges, Manfred Jücker, Jean‐Paul Thiery, Cathrin Brisken, Sabine Riethdorf, Catherine Alix‐Panabières, Klaus Pantel
Published in EMBO Molecular Medicine (2020-07-01)Get full text
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