Search Results - Simon J. Clark

Simon J. Clark

Simon J. Clark is a British protein biochemist, immunologist, and academic, most known for the study of the complement system. He is the holder of the Helmut Ecker Endowed Professorship in Age-related Macular Degeneration at the University of Tübingen, Germany, where he is the head of the Clark Lab that studies the molecular mechanisms driving ocular disease. He is an honorary professor at the University of Manchester, UK, and is a co-founder of Complement Therapeutics.

Clark's research focuses on the complement system, with an emphasis on the role of the extracellular matrix in regulating immunity and inflammation, particularly in ocular health and the blinding disease age-related macular degeneration. His work has led to multiple patents. His studies have been supported by grants from institutions such as the German Research Foundation (DFG), Fight for Sight, and the Medical Research Council (UK). In 2018, he was honored with Macular Society's Rising Star of the Year Award and in 2025 the SVAR Complement Excellence Award. Provided by Wikipedia
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  1. 1

    The proteoglycan glycomatrix: a sugar microenvironment essential for complement regulation by Simon J Clark, Paul N Bishop, Anthony J Day

    Published in Frontiers in Immunology (2013-11-01)
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  2. 2

    The AMD-associated genetic polymorphism CFH Y402H confers vulnerability to Hydroquinone-induced stress in iPSC-RPE cells by Angela Armento, Inga Sonntag, Ana-Cristina Almansa-Garcia, Merve Sen, Sylvia Bolz, Blanca Arango-Gonzalez, Ellen Kilger, Ruchi Sharma, Kapil Bharti, Rosario Fernandez-Godino, Berta de la Cerda, Simon J. Clark, Simon J. Clark, Simon J. Clark, Marius Ueffing

    Published in Frontiers in Immunology (2025-02-01)
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  3. 3

    The impact of substrate stiffness on morphological, transcriptional and functional aspects in RPE by Lasse Wolfram, Clara Gimpel, Melanie Schwämmle, Simon J. Clark, Daniel Böhringer, Günther Schlunck

    Published in Scientific Reports (2024-03-01)
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  4. 4

    Age and Smoking Related Changes in Metal Ion Levels in Human Lens: Implications for Cataract Formation. by Alex Langford-Smith, Viranga Tilakaratna, Paul R Lythgoe, Simon J Clark, Paul N Bishop, Anthony J Day

    Published in PLoS ONE (2016-01-01)
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  5. 5

    Outer retina micro-inflammation is driven by T cell responses prior to retinal degeneration in early age-related macular degeneration by Lucas Stürzbecher, Lucas Stürzbecher, Lucas Stürzbecher, Lucas Stürzbecher, Hendrik Bartolomaeus, Hendrik Bartolomaeus, Hendrik Bartolomaeus, Hendrik Bartolomaeus, Theda U. P. Bartolomaeus, Theda U. P. Bartolomaeus, Theda U. P. Bartolomaeus, Theda U. P. Bartolomaeus, Sylvia Bolz, Andjela Sekulic, Marius Ueffing, Marius Ueffing, Simon J. Clark, Simon J. Clark, Simon J. Clark, Nadine Reichhart, Sergio Crespo-Garcia, Nicola Wilck, Nicola Wilck, Nicola Wilck, Nicola Wilck, Olaf Strauß

    Published in Frontiers in Immunology (2025-02-01)
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  6. 6

    mTOR Inhibition via Rapamycin Treatment Partially Reverts the Deficit in Energy Metabolism Caused by FH Loss in RPE Cells by David A. Merle, Francesca Provenzano, Mohamed Ali Jarboui, Ellen Kilger, Simon J. Clark, Michela Deleidi, Angela Armento, Marius Ueffing

    Published in Antioxidants (2021-12-01)
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  7. 7

    Extra-viral DNA in adeno-associated viral vector preparations induces TLR9-dependent innate immune responses in human plasmacytoid dendritic cells by Kirsten Bucher, Eduardo Rodríguez-Bocanegra, Bernd Wissinger, Torsten Strasser, Simon J. Clark, Andreas L. Birkenfeld, Dorothea Siegel-Axel, M. Dominik Fischer

    Published in Scientific Reports (2023-02-01)
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  8. 8

    Delivery Systems in Ocular Retinopathies: The Promising Future of Intravitreal Hydrogels as Sustained-Release Scaffolds by Diana Rafael, Marcelo Guerrero, Adolfo Marican, Diego Arango, Bruno Sarmento, Roser Ferrer, Esteban F. Durán-Lara, Simon J. Clark, Simo Schwartz

    Published in Pharmaceutics (2023-05-01)
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  9. 9

    Complement Factor H Loss in RPE Cells Causes Retinal Degeneration in a Human RPE-Porcine Retinal Explant Co-Culture Model by Angela Armento, Aparna Murali, Julia Marzi, Ana C Almansa-Garcia, Blanca Arango-Gonzalez, Ellen Kilger, Simon J Clark, Katja Schenke-Layland, Charmaine A Ramlogan-Steel, Jason C Steel, Marius Ueffing

    Published in Biomolecules (2021-11-01)
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  10. 10

    Whole-genome methylation profiling of the retinal pigment epithelium of individuals with age-related macular degeneration reveals differential methylation of the SKI, GTF2H4, and T... by Louise F. Porter, Neil Saptarshi, Yongxiang Fang, Sonika Rathi, Anneke I. den Hollander, Eiko K. de Jong, Simon J. Clark, Paul N. Bishop, Timothy W. Olsen, Triantafillos Liloglou, Venkata R. M. Chavali, Luminita Paraoan

    Published in Clinical Epigenetics (2019-01-01)
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