Search Results - Uwe Grether

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  1. 1

    Therapeutic Potential of Cannabinoid Receptors Type 1 and 2—Novel Insights for Enhancing the Chance of Clinical Success by Uwe Grether

    Published in Pharmaceuticals (2025-09-01)
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  2. 2

    Editorial: Therapeutic potential of the cannabinoid CB2 receptor by Reem Smoum, Uwe Grether, Meliha Karsak, Andrea J. Vernall, Frank Park, Cecilia J. Hillard, Pal Pacher

    Published in Frontiers in Pharmacology (2022-10-01)
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  3. 3

    Identifying opportunities for late-stage C-H alkylation with high-throughput experimentation and in silico reaction screening by David F. Nippa, Kenneth Atz, Alex T. Müller, Jens Wolfard, Clemens Isert, Martin Binder, Oliver Scheidegger, David B. Konrad, Uwe Grether, Rainer E. Martin, Gisbert Schneider

    Published in Communications Chemistry (2023-11-01)
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  4. 4

    Relevance of a peripheral site of action outside the brain-blood barrier for the beneficial effects of CB2 receptor activation in experimental ALS in male mice by Marta Gómez-Almería, Claudia Gonzalo-Consuegra, Carmen Rodríguez-Cueto, María Cabañas-Cotillas, Alberto Jiménez-Amor, Isabel Machín-Díaz, Matthias B. Wittwer, Pawel Dzygiel, Diego Clemente, Uwe Grether, Javier Fernández-Ruiz, Eva de Lago

    Published in Cell Communication and Signaling (2025-10-01)
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  5. 5

    Author Correction: Prospective de novo drug design with deep interactome learning by Kenneth Atz, Leandro Cotos, Clemens Isert, Maria Håkansson, Dorota Focht, Mattis Hilleke, David F. Nippa, Michael Iff, Jann Ledergerber, Carl C. G. Schiebroek, Valentina Romeo, Jan A. Hiss, Daniel Merk, Petra Schneider, Bernd Kuhn, Uwe Grether, Gisbert Schneider

    Published in Nature Communications (2025-01-01)
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  6. 6

    Prospective de novo drug design with deep interactome learning by Kenneth Atz, Leandro Cotos, Clemens Isert, Maria Håkansson, Dorota Focht, Mattis Hilleke, David F. Nippa, Michael Iff, Jann Ledergerber, Carl C. G. Schiebroek, Valentina Romeo, Jan A. Hiss, Daniel Merk, Petra Schneider, Bernd Kuhn, Uwe Grether, Gisbert Schneider

    Published in Nature Communications (2024-04-01)
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  7. 7

    Multiple intramolecular triggers converge to preferential G protein coupling in the CB2R by Adrian Morales-Pastor, Tamara Miljuš, Miguel Dieguez-Eceolaza, Tomasz Maciej Stępniewski, Vicente Ledesma-Martin, Franziska M. Heydenreich, Tilman Flock, Bianca Plouffe, Christian Le Gouill, Jean Duchaine, David A. Sykes, Colin Nicholson, Eline J. Koers, Wolfgang Guba, Arne C. Rufer, Uwe Grether, Michel Bouvier, Dmitry B. Veprintsev, Jana Selent

    Published in Nature Communications (2025-06-01)
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  8. 8

    Development of a membrane-based Gi-CASE biosensor assay for profiling compounds at cannabinoid receptors by Morgan Scott-Dennis, Morgan Scott-Dennis, Fikri A. Rafani, Fikri A. Rafani, Yicheng Yi, Yicheng Yi, Themiya Perera, Themiya Perera, Clare R. Harwood, Clare R. Harwood, Wolfgang Guba, Arne C. Rufer, Uwe Grether, Dmitry B. Veprintsev, Dmitry B. Veprintsev, Dmitry B. Veprintsev, David A. Sykes, David A. Sykes, David A. Sykes

    Published in Frontiers in Pharmacology (2023-08-01)
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  9. 9

    Flipping the GPCR Switch: Structure-Based Development of Selective Cannabinoid Receptor 2 Inverse Agonists by Miroslav Kosar, Roman C. Sarott, David A. Sykes, Alexander E. G. Viray, Rosa Maria Vitale, Nataša Tomašević, Xiaoting Li, Rudolf L. Z. Ganzoni, Bilal Kicin, Lisa Reichert, Kacper J. Patej, Uxía Gómez-Bouzó, Wolfgang Guba, Peter J. McCormick, Tian Hua, Christian W. Gruber, Dmitry B. Veprintsev, James A. Frank, Uwe Grether, Erick M. Carreira

    Published in ACS Central Science (2024-03-01)
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  10. 10

    RG7774 (Vicasinabin), an orally bioavailable cannabinoid receptor 2 (CB2R) agonist, decreases retinal vascular permeability, leukocyte adhesion, and ocular inflammation in animal m... by Uwe Grether, Richard H. Foxton, Sabine Gruener, Claudia Korn, Atsushi Kimbara, Anja Osterwald, Elisabeth Zirwes, Sabine Uhles, Janina Thoele, Nadine Colé, Mark Rogers-Evans, Stephan Röver, Matthias Nettekoven, Rainer E. Martin, Jean-Michel Adam, Jürgen Fingerle, Caterina Bissantz, Wolfgang Guba, André Alker, Anna M. Szczesniak, Ross F. Porter, Tom J. Toguri, Franco Revelant, Agnès Poirier, Camille Perret, Lotte Winther, Antonello Caruso, Filomena Fezza, Mauro Maccarrone, Mauro Maccarrone, Melanie E. M. Kelly, Sascha Fauser, Christoph Ullmer

    Published in Frontiers in Pharmacology (2024-07-01)
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  11. 11

    A universal cannabinoid CB1 and CB2 receptor TR-FRET kinetic ligand-binding assay by Leire Borrega-Roman, Leire Borrega-Roman, Leire Borrega-Roman, Leire Borrega-Roman, Bradley L. Hoare, Bradley L. Hoare, Miroslav Kosar, Roman C. Sarott, Kacper J. Patej, Jara Bouma, Morgan Scott-Dennis, Morgan Scott-Dennis, Eline J. Koers, Eline J. Koers, Thais Gazzi, Leonard Mach, Sergio Barrondo, Sergio Barrondo, Sergio Barrondo, Joan Sallés, Joan Sallés, Joan Sallés, Wolfgang Guba, Eric Kusznir, Marc Nazaré, Arne C. Rufer, Uwe Grether, Laura H. Heitman, Erick M. Carreira, David A. Sykes, David A. Sykes, Dmitry B. Veprintsev, Dmitry B. Veprintsev

    Published in Frontiers in Pharmacology (2025-04-01)
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  12. 12

    A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence by Ming Jiang, Mirjam C. W. Huizenga, Jonah L. Wirt, Janos Paloczi, Avand Amedi, Richard J. B. H. N. van den Berg, Joerg Benz, Ludovic Collin, Hui Deng, Xinyu Di, Wouter F. Driever, Bogdan I. Florea, Uwe Grether, Antonius P. A. Janssen, Thomas Hankemeier, Laura H. Heitman, Tsang-Wai Lam, Florian Mohr, Anto Pavlovic, Iris Ruf, Helma van den Hurk, Anna F. Stevens, Daan van der Vliet, Tom van der Wel, Matthias B. Wittwer, Constant A. A. van Boeckel, Pal Pacher, Andrea G. Hohmann, Mario van der Stelt

    Published in Nature Communications (2023-12-01)
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  13. 13

    Enhancing Drug Discovery and Development through the Integration of Medicinal Chemistry, Chemical Biology, and Academia-Industry Partnerships: Insights from Roche’s Endocannabinoid... by Johannes Aebi, Kenneth Atz, Simon M. Ametamey, Jörg Benz, Julie Blaising, Stefania Butini, Giuseppe Campiani, Erick M. Carreira, Ludovic Collin, Eva de Lago, Thais Gazzi, Jürg Gertsch, Luca Gobbi, Wolfgang Guba, Javier Fernández-Ruiz, Jürgen Fingerle, Achi Haider, Yingfang He, Laura H. Heitman, Michael Honer, Daniel Hunziker, Bernd Kuhn, Mauro Maccarrone, Hans Peter Märki, Rainer E. Martin, Peter Mohr, Linjing Mu, Marc Nazaré, David F. Nippa, Sergio Oddi, Fionn O’Hara, Pal Pacher, Julian Romero, Stephan Röver, Arne C. Rufer, Roger Schibli, Gisbert Schneider, Antonia F. Stepan, David A. Sykes, Christoph Ullmer, Mario van der Stelt, Dmitry B. Veprintsev, Matthias B. Wittwer, Uwe Grether

    Published in CHIMIA (2024-08-01)
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