Angiomyofibroblastoma of the scrotum: A report of two cases and literature review

Angiomyofibroblastoma is a rare benign mesenchymal tumor typically found in the genital region of adult females, but its occurrence in the male scrotum is exceptionally uncommon. This report presents two cases of angiomyofibroblastoma in the male scrotum to enhance the understanding of this rare con...

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Bibliographic Details
Published in:Journal of International Medical Research
Main Authors: Qifan Xie, Chujin Ye, Hanzhong Chen, Zhiye Liu, Kun Wei, Fangqianyu Zhong, Xiaoyong Pu, Shang Huang
Format: Article
Language:English
Published: SAGE Publishing 2025-10-01
Online Access:https://doi.org/10.1177/03000605251386617
Description
Summary:Angiomyofibroblastoma is a rare benign mesenchymal tumor typically found in the genital region of adult females, but its occurrence in the male scrotum is exceptionally uncommon. This report presents two cases of angiomyofibroblastoma in the male scrotum to enhance the understanding of this rare condition. In the first case, a man in his early 60s with a recent rectal cancer diagnosis was found to have a palpable right scrotal mass. Imaging suggested metastasis, but radical resection and pathological analysis confirmed angiomyofibroblastoma, with no evidence of testicular malignancy. The patient remained tumor-free for 7 years. In the second case, a man in his early 40s presented with a nontender, slowly enlarging right inguinal mass extending into the scrotum. Surgical resection revealed a 6 × 4-cm angiomyofibroblastoma, with no recurrence for 7 years. These cases underscore the importance of considering angiomyofibroblastoma in the differential diagnosis of scrotal masses in males. Accurate diagnosis relies on understanding the clinical, imaging, and histopathologic features of angiomyofibroblastoma to ensure appropriate management and favorable outcomes.
ISSN:1473-2300