Antimicrobial compound from Trichoderma harzianum, an endophytic fungus associated with ginger (Zingiber officinale)
Background: Genus Trichoderma of fungal kingdom are largely used as biological control agents due to broad-spectrum activity against plant pathogens. Objective: This study aimed to investigate Trichoderma harzianum, an endophytic fungus obtained from ginger (Zingiber officinale) leaves. Methods: The...
| Published in: | JKKI (Jurnal Kedokteran dan Kesehatan Indonesia) |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
| Published: |
Faculty of Medicine
2021-08-01
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| Subjects: | |
| Online Access: | https://journal.uii.ac.id/JKKI/article/view/18839 |
| Summary: | Background: Genus Trichoderma of fungal kingdom are largely used as biological control agents due to broad-spectrum activity against plant pathogens.
Objective: This study aimed to investigate Trichoderma harzianum, an endophytic fungus obtained from ginger (Zingiber officinale) leaves.
Methods: The chemical structures of the isolated compounds were deduced on the basis of UV, 1H NMR and MS data analyses, as well as comparison with literature.
Results: Two known tetramic acid derivatives were isolated from this fungus, including harzianic acid (A) and isoharzianic acid (B). Compound B inhibited the growth of a corn pathogenic fungus, Ustilago maydis, with inhibition zone diameter (39 ± 0.33 mm) larger than nystatin (29 mm). Additionally, iso-HA (B) revealed antibacterial effect towards Staphylococcus aureus with MIC value of 25 µM. However, both compounds showed no cytotoxicity against human cervical and ovarian cancer cell lines.
Conclusion: T. harzianum produced antimicrobial compound like iso-HA which has potential application either in agricultural or health. |
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| ISSN: | 2085-4145 2527-2950 |