Sweroside alleviates pressure overload-induced heart failure through targeting CaMKⅡδ to inhibit ROS-mediated NF-κB/NLRP3 in cardiomyocytes

Ongoing inflammation in the heart is positively correlated with adverse remodeling, characterized by elevated levels of cytokines that stimulate activation of cardiac fibroblasts. It was found that CaMKIIδ response to Ang II or TAC triggers the accumulation of ROS in cardiomyocytes, which subsequent...

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Bibliographic Details

Published in:	Redox Biology
Main Authors:	Dong Wang, Xue Yu, Kuo Gao, Fanghe Li, Xiang Li, Haiyin Pu, Peng Zhang, Shuzhen Guo, Wei Wang
Format:	Article
Language:	English
Published:	Elsevier 2024-08-01
Subjects:	Sweroside Inflammation Cardiac remodeling Heart failure Cardiomyocytes
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213231724002015