A Survey of Synthetic Routes and Antitumor Activities for Benzo[<i>g</i>]quinoxaline-5,10-diones
Anthracycline antibiotics play an important role in cancer chemotherapy. The need to improve their therapeutic index has stimulated an ongoing search for anthracycline analogs with enhanced properties. This review aims to summarize the common synthetic approaches to benzo[<i>g</i>]quinox...
| Published in: | Molecules |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-12-01
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| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/25/24/5922 |
| _version_ | 1851832755693813760 |
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| author | Alain G. Giuglio-Tonolo Christophe Curti Thierry Terme Patrice Vanelle |
| author_facet | Alain G. Giuglio-Tonolo Christophe Curti Thierry Terme Patrice Vanelle |
| author_sort | Alain G. Giuglio-Tonolo |
| collection | DOAJ |
| container_title | Molecules |
| description | Anthracycline antibiotics play an important role in cancer chemotherapy. The need to improve their therapeutic index has stimulated an ongoing search for anthracycline analogs with enhanced properties. This review aims to summarize the common synthetic approaches to benzo[<i>g</i>]quinoxaline-5,10-diones and their uses in heterocyclic chemistry. Because of the valuable biological activities of the 1,4-diazaanthraquinone compounds, a summary of the most promising heterocyclic quinones is provided together with their antitumor properties. |
| format | Article |
| id | doaj-art-00aad7044fd64129825e188ce642195b |
| institution | Directory of Open Access Journals |
| issn | 1420-3049 |
| language | English |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| spelling | doaj-art-00aad7044fd64129825e188ce642195b2025-08-19T22:31:30ZengMDPI AGMolecules1420-30492020-12-012524592210.3390/molecules25245922A Survey of Synthetic Routes and Antitumor Activities for Benzo[<i>g</i>]quinoxaline-5,10-dionesAlain G. Giuglio-Tonolo0Christophe Curti1Thierry Terme2Patrice Vanelle3Equipe Pharmaco-Chimie Radicalaire, Faculté de Pharmacie, Institut de Chimie Radicalaire, Aix Marseille Université, CNRS, UMR 7273, 27 Boulevard Jean Moulin, CEDEX 05, 13385 Marseille, FranceEquipe Pharmaco-Chimie Radicalaire, Faculté de Pharmacie, Institut de Chimie Radicalaire, Aix Marseille Université, CNRS, UMR 7273, 27 Boulevard Jean Moulin, CEDEX 05, 13385 Marseille, FranceEquipe Pharmaco-Chimie Radicalaire, Faculté de Pharmacie, Institut de Chimie Radicalaire, Aix Marseille Université, CNRS, UMR 7273, 27 Boulevard Jean Moulin, CEDEX 05, 13385 Marseille, FranceEquipe Pharmaco-Chimie Radicalaire, Faculté de Pharmacie, Institut de Chimie Radicalaire, Aix Marseille Université, CNRS, UMR 7273, 27 Boulevard Jean Moulin, CEDEX 05, 13385 Marseille, FranceAnthracycline antibiotics play an important role in cancer chemotherapy. The need to improve their therapeutic index has stimulated an ongoing search for anthracycline analogs with enhanced properties. This review aims to summarize the common synthetic approaches to benzo[<i>g</i>]quinoxaline-5,10-diones and their uses in heterocyclic chemistry. Because of the valuable biological activities of the 1,4-diazaanthraquinone compounds, a summary of the most promising heterocyclic quinones is provided together with their antitumor properties.https://www.mdpi.com/1420-3049/25/24/5922benzo[<i>g</i>]quinoxaline-5,10-dione1,4-diazaanthraquinoneanthracene-9,10-dione |
| spellingShingle | Alain G. Giuglio-Tonolo Christophe Curti Thierry Terme Patrice Vanelle A Survey of Synthetic Routes and Antitumor Activities for Benzo[<i>g</i>]quinoxaline-5,10-diones benzo[<i>g</i>]quinoxaline-5,10-dione 1,4-diazaanthraquinone anthracene-9,10-dione |
| title | A Survey of Synthetic Routes and Antitumor Activities for Benzo[<i>g</i>]quinoxaline-5,10-diones |
| title_full | A Survey of Synthetic Routes and Antitumor Activities for Benzo[<i>g</i>]quinoxaline-5,10-diones |
| title_fullStr | A Survey of Synthetic Routes and Antitumor Activities for Benzo[<i>g</i>]quinoxaline-5,10-diones |
| title_full_unstemmed | A Survey of Synthetic Routes and Antitumor Activities for Benzo[<i>g</i>]quinoxaline-5,10-diones |
| title_short | A Survey of Synthetic Routes and Antitumor Activities for Benzo[<i>g</i>]quinoxaline-5,10-diones |
| title_sort | survey of synthetic routes and antitumor activities for benzo i g i quinoxaline 5 10 diones |
| topic | benzo[<i>g</i>]quinoxaline-5,10-dione 1,4-diazaanthraquinone anthracene-9,10-dione |
| url | https://www.mdpi.com/1420-3049/25/24/5922 |
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