Long non coding RNAs and ALS: Still much to do

Alterations in RNA metabolism play an important role in Amyotrophic Lateral Sclerosis (ALS) pathogenesis. The literature has described, so far, a small number of long non coding RNAs (lncRNAs) associated to ALS demonstrating that how there is still much to do to identify and understand their role in...

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Bibliographic Details
Published in:Non-coding RNA Research
Main Authors: Stella Gagliardi, Cecilia Pandini, Maria Garofalo, Matteo Bordoni, Orietta Pansarasa, Cristina Cereda
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2018-12-01
Online Access:http://www.sciencedirect.com/science/article/pii/S2468054018300891
Description
Summary:Alterations in RNA metabolism play an important role in Amyotrophic Lateral Sclerosis (ALS) pathogenesis. The literature has described, so far, a small number of long non coding RNAs (lncRNAs) associated to ALS demonstrating that how there is still much to do to identify and understand their role in ALS. This class of RNAs may offer numerous starting points for new investigations about pathogenic mechanism involved in ALS disease. In this review, we have collected all the presented data about lncRNAs and ALS to offer an overview about this class of non-coding RNAs and their possible role in ALS disease. Keywords: ALS, lncRNAs
ISSN:2468-0540

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