Epidemiological and genomic findings of the first documented Italian outbreak of SARS-CoV-2 Alpha variant of concern
From 24 December 2020 to 8 February 2021, 163 cases of SARS-CoV-2 Alpha variant of concern (VOC) were identified in Chieti province, Abruzzo region. Epidemiological data allowed the identification of 14 epi-clusters. With one exception, all the epi-clusters were linked to the town of Guardiagrele: 1...
| Published in: | Epidemics |
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| Main Authors: | , , , , , , , , , , , , , , , , , |
| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1755436522000287 |
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| author | Laura Amato Luca Candeloro Arturo Di Girolamo Lara Savini Ilaria Puglia Maurilia Marcacci Marialuigia Caporale Iolanda Mangone Cesare Cammà Annamaria Conte Giuseppe Torzi Adamo Mancinelli Francesca Di Giallonardo Alessio Lorusso Giacomo Migliorati Thomas Schael Nicola D’Alterio Paolo Calistri |
| author_facet | Laura Amato Luca Candeloro Arturo Di Girolamo Lara Savini Ilaria Puglia Maurilia Marcacci Marialuigia Caporale Iolanda Mangone Cesare Cammà Annamaria Conte Giuseppe Torzi Adamo Mancinelli Francesca Di Giallonardo Alessio Lorusso Giacomo Migliorati Thomas Schael Nicola D’Alterio Paolo Calistri |
| author_sort | Laura Amato |
| collection | DOAJ |
| container_title | Epidemics |
| description | From 24 December 2020 to 8 February 2021, 163 cases of SARS-CoV-2 Alpha variant of concern (VOC) were identified in Chieti province, Abruzzo region. Epidemiological data allowed the identification of 14 epi-clusters. With one exception, all the epi-clusters were linked to the town of Guardiagrele: 149 contacts formed the network, two-thirds of which were referred to the family/friends context. Real data were then used to estimate transmission parameters. According to our method, the calculated Re(t) was higher than 2 before the 12 December 2020. Similar values were obtained from other studies considering Alpha VOC. Italian sequence data were combined with a random subset of sequences obtained from the GISAID database. Genomic analysis showed close identity between the sequences from Guardiagrele, forming one distinct clade. This would suggest one or limited unspecified viral introductions from outside to Abruzzo region in early December 2020, which led to the diffusion of Alpha VOC in Guardiagrele and in neighbouring municipalities, with very limited inter-regional mixing. |
| format | Article |
| id | doaj-art-02441cf4c0a74b15b4e342f424a4cc5c |
| institution | Directory of Open Access Journals |
| issn | 1755-4365 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| spelling | doaj-art-02441cf4c0a74b15b4e342f424a4cc5c2025-08-19T22:09:43ZengElsevierEpidemics1755-43652022-06-013910057810.1016/j.epidem.2022.100578Epidemiological and genomic findings of the first documented Italian outbreak of SARS-CoV-2 Alpha variant of concernLaura Amato0Luca Candeloro1Arturo Di Girolamo2Lara Savini3Ilaria Puglia4Maurilia Marcacci5Marialuigia Caporale6Iolanda Mangone7Cesare Cammà8Annamaria Conte9Giuseppe Torzi10Adamo Mancinelli11Francesca Di Giallonardo12Alessio Lorusso13Giacomo Migliorati14Thomas Schael15Nicola D’Alterio16Paolo Calistri17Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise “G. Caporale” (IZSAM), 64100 Teramo, Italy; Corresponding author.Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise “G. Caporale” (IZSAM), 64100 Teramo, ItalyLanciano-Vasto-Chieti Local Health Unit, 66100 Chieti, ItalyIstituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise “G. Caporale” (IZSAM), 64100 Teramo, ItalyIstituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise “G. Caporale” (IZSAM), 64100 Teramo, ItalyIstituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise “G. Caporale” (IZSAM), 64100 Teramo, ItalyIstituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise “G. Caporale” (IZSAM), 64100 Teramo, ItalyIstituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise “G. Caporale” (IZSAM), 64100 Teramo, ItalyIstituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise “G. Caporale” (IZSAM), 64100 Teramo, ItalyIstituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise “G. Caporale” (IZSAM), 64100 Teramo, ItalyLanciano-Vasto-Chieti Local Health Unit, 66100 Chieti, ItalyLanciano-Vasto-Chieti Local Health Unit, 66100 Chieti, ItalyThe Kirby Institute, UNSW Sydney, Sydney, NSW 2052, AustraliaIstituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise “G. Caporale” (IZSAM), 64100 Teramo, ItalyIstituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise “G. Caporale” (IZSAM), 64100 Teramo, ItalyLanciano-Vasto-Chieti Local Health Unit, 66100 Chieti, ItalyIstituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise “G. Caporale” (IZSAM), 64100 Teramo, ItalyIstituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise “G. Caporale” (IZSAM), 64100 Teramo, ItalyFrom 24 December 2020 to 8 February 2021, 163 cases of SARS-CoV-2 Alpha variant of concern (VOC) were identified in Chieti province, Abruzzo region. Epidemiological data allowed the identification of 14 epi-clusters. With one exception, all the epi-clusters were linked to the town of Guardiagrele: 149 contacts formed the network, two-thirds of which were referred to the family/friends context. Real data were then used to estimate transmission parameters. According to our method, the calculated Re(t) was higher than 2 before the 12 December 2020. Similar values were obtained from other studies considering Alpha VOC. Italian sequence data were combined with a random subset of sequences obtained from the GISAID database. Genomic analysis showed close identity between the sequences from Guardiagrele, forming one distinct clade. This would suggest one or limited unspecified viral introductions from outside to Abruzzo region in early December 2020, which led to the diffusion of Alpha VOC in Guardiagrele and in neighbouring municipalities, with very limited inter-regional mixing.http://www.sciencedirect.com/science/article/pii/S1755436522000287AbruzzoSARS-CoV-2, Alpha variantEpidemiologyGenomic surveillanceReproduction number |
| spellingShingle | Laura Amato Luca Candeloro Arturo Di Girolamo Lara Savini Ilaria Puglia Maurilia Marcacci Marialuigia Caporale Iolanda Mangone Cesare Cammà Annamaria Conte Giuseppe Torzi Adamo Mancinelli Francesca Di Giallonardo Alessio Lorusso Giacomo Migliorati Thomas Schael Nicola D’Alterio Paolo Calistri Epidemiological and genomic findings of the first documented Italian outbreak of SARS-CoV-2 Alpha variant of concern Abruzzo SARS-CoV-2, Alpha variant Epidemiology Genomic surveillance Reproduction number |
| title | Epidemiological and genomic findings of the first documented Italian outbreak of SARS-CoV-2 Alpha variant of concern |
| title_full | Epidemiological and genomic findings of the first documented Italian outbreak of SARS-CoV-2 Alpha variant of concern |
| title_fullStr | Epidemiological and genomic findings of the first documented Italian outbreak of SARS-CoV-2 Alpha variant of concern |
| title_full_unstemmed | Epidemiological and genomic findings of the first documented Italian outbreak of SARS-CoV-2 Alpha variant of concern |
| title_short | Epidemiological and genomic findings of the first documented Italian outbreak of SARS-CoV-2 Alpha variant of concern |
| title_sort | epidemiological and genomic findings of the first documented italian outbreak of sars cov 2 alpha variant of concern |
| topic | Abruzzo SARS-CoV-2, Alpha variant Epidemiology Genomic surveillance Reproduction number |
| url | http://www.sciencedirect.com/science/article/pii/S1755436522000287 |
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