Development and validation of liquid chromatography-tandem mass spectrometry method to quantify dasatinib in plasma and its application to a pharmacokinetic study

Abstract Dasatinib, a potent oral multi-targeted kinase inhibitor against Src and Bcr-Abl, can decrease inflammatory response in sepsis. A simple and cost-effective method for determination of an effective dose dasatinib was established. This method was validated in human plasma, with the aim of red...

Full description

Bibliographic Details
Published in:	Brazilian Journal of Pharmaceutical Sciences
Main Authors:	Edlaine Rijo Costa, Thales Nascimento Castro, Cassiano Felippe Gonçalves-de-Albuquerque, Hugo Caire de Castro Faria Neto, José Carlos Saraiva Gonçalves, Rita de Cássia Elias Estrela
Format:	Article
Language:	English
Published:	Universidade de São Paulo 2023-05-01
Subjects:	LC-MS/MS Liquid-liquid extraction Dasatinib Mice plasma Pharmacokinetics
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502023000100340&lng=en&tlng=en

Similar Items

Bioanalysis of bedaquiline in human plasma by liquid chromatography-tandem mass spectrometry: Application to pharmacokinetic study
by: Viritha Bezawada, et al.
Published: (2024-01-01)

Development and Validation of Liquid Chromatography-Tandem Mass Spectrometry Method for Simple Analysis of Sumatriptan and its Application in Bioequivalence Study
by: Wisut Wichitnithad, et al.
Published: (2020-01-01)

Pharmacokinetics of Dasatinib
by: Jana Hořínková, et al.
Published: (2019-10-01)

Validation of a Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry Method for Determination of All-Trans Retinoic Acid in Human Plasma and Its Application to a Bioequivalence Study
by: Jing-Bo Peng, et al.
Published: (2014-01-01)

Determination of 20 Pesticide Residues in Cosmetic Containing Plant Extracts by Liquid Chromatography Tandem Mass Spectrometry
by: YANG Jin-qing, et al.
Published: (2021-11-01)

Quantification of tolvaptan in rabbit plasma by LC–MS/MS: Application to a pharmacokinetic study
by: Kumar S. Moola, et al.
Published: (2015-12-01)

Simultaneous Determination of Coumarin and Its Derivatives in Tobacco Products by Liquid Chromatography-Tandem Mass Spectrometry
by: Zhiqin Ren, et al.
Published: (2016-11-01)

Population Pharmacokinetics of Dasatinib in Healthy Subjects
by: Walaa B. Hassouneh, et al.
Published: (2024-05-01)

Formulation Characterization and Pharmacokinetic Evaluation of Amorphous Solid Dispersions of Dasatinib
by: Sathish Dharani, et al.
Published: (2022-11-01)

Dasatinib-Related Chylothorax
by: Yen Min Huang, et al.
Published: (2015-02-01)

Determination of Cannabinoids in Meat Products and Animal Feeds in Singapore Using Liquid Chromatography–Tandem Mass Spectrometry
by: Jia En Valerie Sin, et al.
Published: (2024-08-01)

Determination of 11 kinds of pesticide residues in liquid milk by dispersive solid phase extraction coupled with ultra performance liquid chromatography-tandem mass spectrometry
by: HUANG Mangu, et al.
Published: (2024-01-01)

Uncertainty evaluation for the determination of four quinolone residues in honey by liquid chromatography-tandem mass spectrometry
by: YANG Yun, et al.
Published: (2024-04-01)

Quantitative Determination of Bisphenol A and Its Congeners in Plant-Based Beverages by Liquid Chromatography Coupled to Tandem Mass Spectrometry
by: Marica Erminia Schiano, et al.
Published: (2022-11-01)

A practical approach to supported liquid extraction and measurement of 18 steroids in plasma and serum by targeted liquid chromatography tandem mass spectrometry
by: Scott G Denham, et al.
Published: (2024-06-01)

Determination of Residual Behavior of Flufenacet in Wheat and its Dietary Risk Assessment by Liquid Chromatography-Tandem Mass Spectrometry
by: Jing YANG, et al.
Published: (2025-05-01)

A strange cause of chylothorax- Dasatinib induced
by: M Natraj, et al.
Published: (2018-01-01)

A Label-Free Liquid Chromatography–Tandem Mass Spectrometry Method for the Quantitative Analysis of Exosome Pharmacokinetics In Vivo
by: Bingxuan Li, et al.
Published: (2025-05-01)

Determination of 47 Pesticide Residues in Tea by QuEChERS Method Combined with Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry
by: Huawen LIU, et al.
Published: (2024-05-01)

Determination of mitomycin C in rat plasma by liquid chromatography-tandem mass spectrometry and its application for determining pharmacokinetics in rat
by: Kyung-Sun Moon, et al.
Published: (2024-06-01)

Effects of triglycerides levels in human whole blood on the extraction of 19 commonly used drugs using liquid–liquid extraction and gas chromatography–mass spectrometry
by: ZhiBin Huang, et al.
Published: (2015-01-01)

Detection of six common trichothecene toxins in oats by ultra-high performance liquid chromatography-tandem mass spectrometry
by: CHEN Po, et al.
Published: (2024-07-01)

Pharmacokinetics of dasatinib for Philadelphia-positive acute lymphocytic leukemia with acquired T315I mutation
by: Takahashi Naoto, et al.
Published: (2012-05-01)

Carrier-free prodrug nanoparticles based on dasatinib and cisplatin for efficient antitumor in vivo
by: Lu Yang, et al.
Published: (2021-11-01)

Dasatinib-induced chylothorax beyond 5 years of treatment: is there actually any limit?
by: Alberto Garcia-Zamalloa, et al.
Published: (2023-06-01)

Stability Evaluation and Pharmacokinetic Profiling of Vepdegestrant in Rodents Using Liquid Chromatography–Tandem Mass Spectrometry
by: Hae-In Choi, et al.
Published: (2024-08-01)

Pharmacokinetic study of Q808 in rhesus monkey using liquid chromatography–tandem mass spectrometry
by: Ning Xiao, et al.
Published: (2024-07-01)

Determination of 28 Drug Residues in Lamb by Modified QuEChERs-Ultra High Performance Liquid Chromatography Tandem Mass Spectrometry
by: JI Bao-cheng;HAN Yu;YANG Lan-rui ;XU Xu;BAI Yan-hong;LI Wen-qin;CHEN Jiang-hong;LIU Yun-ke
Published: (2023-05-01)

Development of a Liquid Chromatography–Tandem Mass Spectrometry (LC–MS/MS) Method for Characterizing Linalool Oral Pharmacokinetics in Humans
by: Yan-Hong Wang, et al.
Published: (2023-09-01)

Extraction and identification of terrestrial snail pheromones using liquid-liquid extraction technique followed by gas chromatography-mass spectrometry
by: Milad Ghani, et al.
Published: (2022-09-01)

An Ultra-Performance Liquid Chromatography–Tandem Mass Spectrometry (UPLC–MS/MS) Method for Qualifying DAPB in Rat Plasma and Application to Pharmacokinetic Studies
by: Bei Qin, et al.
Published: (2024-01-01)

Development and Validation of a LC-ESI-MS/MS Method for the Determination of Alternaria Toxins Alternariol, Alternariol Methyl-Ether and Tentoxin in Tomato and Tomato-Based Products
by: Yelko Rodríguez-Carrasco, et al.
Published: (2016-11-01)

The Effect of Dihydromyricetin on the Pharmacokinetics of Fluconazole in Sprague-Dawley Rat Plasma, Based on High-Performance Liquid Chromatography–Tandem Mass Spectrometry
by: Liu H, et al.
Published: (2023-08-01)

Development and validation of the chromatography-mass spectrometry technique for polyprenols quantitative assessment
by: N. S. Popov, et al.
Published: (2024-06-01)

Progress of liquid chromatography and mass spectrometry-based single-cell proteomics
by: Huo Zian, et al.
Published: (2022-12-01)

QuEChERS combined with ultra-high performance liquid chromatography-tandem mass spectrometry to determine acrylamide in Xinjiang Naan products
by: XU Man, et al.
Published: (2024-11-01)

Residue Degradation and Risk Assessment of Difenoconazole and Its Metabolite during Tea Growing, Processing and Brewing by Ultra-Performance Liquid Chromatography–Tandem Mass Spectrometry Determination
by: Min Wang, et al.
Published: (2024-04-01)

Simultaneous Determination of 76 Veterinary Drugs and Their Metabolites in Pork by QuEChERS-Ultra High Performance Liquid Chromatography-Tandem Mass Spectrometry
by: Yanlei WU, et al.
Published: (2023-10-01)

Simultaneous Method for Selected PBDEs and HBCDDs in Foodstuffs Using Gas Chromatography—Tandem Mass Spectrometry and Liquid Chromatography—Tandem Mass Spectrometry
by: Eva Lipičar, et al.
Published: (2022-12-01)

Dasatinib-induced massive left chylothorax in a patient with chronic myeloid leukemia
by: Go Makimoto, et al.
Published: (2022-01-01)