A Physiologically Based Pharmacokinetic Model Relates the Subcutaneous Bioavailability of Monoclonal Antibodies to the Saturation of FcRn-Mediated Recycling in Injection-Site-Draining Lymph Nodes

The bioavailability of a monoclonal antibody (mAb) or another therapeutic protein after subcutaneous (SC) dosing is challenging to predict from first principles, even if the impact of injection site physiology and drug properties on mAb bioavailability is generally understood. We used a physiologica...

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書誌詳細

出版年:	Antibodies
主要な著者:	Felix Stader, Cong Liu, Abdallah Derbalah, Hiroshi Momiji, Xian Pan, Iain Gardner, Masoud Jamei, Armin Sepp
フォーマット:	論文
言語:	英語
出版事項:	MDPI AG 2024-08-01
主題:	monoclonal antibodies subcutaneous dosing physiologically based pharmacokinetic modeling antigen-presenting cells neonatal Fc receptor (FcRn)
オンライン･アクセス:	https://www.mdpi.com/2073-4468/13/3/70