A Physiologically Based Pharmacokinetic Model Relates the Subcutaneous Bioavailability of Monoclonal Antibodies to the Saturation of FcRn-Mediated Recycling in Injection-Site-Draining Lymph Nodes

The bioavailability of a monoclonal antibody (mAb) or another therapeutic protein after subcutaneous (SC) dosing is challenging to predict from first principles, even if the impact of injection site physiology and drug properties on mAb bioavailability is generally understood. We used a physiologica...

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发表在:	Antibodies
Main Authors:	Felix Stader, Cong Liu, Abdallah Derbalah, Hiroshi Momiji, Xian Pan, Iain Gardner, Masoud Jamei, Armin Sepp
格式:	文件
语言:	英语
出版:	MDPI AG 2024-08-01
主题:	monoclonal antibodies subcutaneous dosing physiologically based pharmacokinetic modeling antigen-presenting cells neonatal Fc receptor (FcRn)
在线阅读:	https://www.mdpi.com/2073-4468/13/3/70