Epigenetic state determines the in vivo efficacy of STING agonist therapy

STING agonists have shown limited efficacy in early-phase clinical trials despite promising pre-clinical data. This study shows the potential clinical relevance of the use of combination STING agonists and demethylating agent therapies to induce the expression of STING.

Bibliographic Details
Published in:Nature Communications
Main Authors: Rana Falahat, Anders Berglund, Patricio Perez-Villarroel, Ryan M. Putney, Imene Hamaidi, Sungjune Kim, Shari Pilon-Thomas, Glen N. Barber, James J. Mulé
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Online Access:https://doi.org/10.1038/s41467-023-37217-1
Description
Summary:STING agonists have shown limited efficacy in early-phase clinical trials despite promising pre-clinical data. This study shows the potential clinical relevance of the use of combination STING agonists and demethylating agent therapies to induce the expression of STING.
ISSN:2041-1723

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