Repurposing Terbutaline and Milrinone for Cancer Therapy: A Comprehensive Review

Cancer remains a leading cause of mortality worldwide, necessitating innovative therapeutic strategies. Drug repurposing offers a cost-effective approach to cancer treatment by identifying new anticancer applications for existing drugs. Terbutaline, a β2-adrenergic receptor agonist, and Milrinone, a...

Full description

Bibliographic Details
Published in:	Future Pharmacology
Main Authors:	Eduarda Ribeiro, Nuno Vale
Format:	Article
Language:	English
Published:	MDPI AG 2025-07-01
Subjects:	β2-adrenergic receptor cancer therapy cAMP signaling drug repurposing milrinone phosphodiesterase-3 inhibitor
Online Access:	https://www.mdpi.com/2673-9879/5/3/38

Similar Items

Role of PDE4 Family in Cardiomyocyte Physiology and Heart Failure
by: Ivan Sherstnev, et al.
Published: (2025-03-01)

Age-Dependent Maturation of iPSC-CMs Leads to the Enhanced Compartmentation of β<sub>2</sub>AR-cAMP Signalling
by: Alveera Hasan, et al.
Published: (2020-10-01)

Non-Selective PDE4 Inhibition Induces a Rapid and Transient Decrease of Serum Potassium in Mice
by: Abigail Boyd, et al.
Published: (2022-10-01)

cAMP-PDE signaling in COPD: Review of cellular, molecular and clinical features
by: Yazdan Hasani Nourian, et al.
Published: (2023-07-01)

Effects of adjunctive milrinone versus placebo on hemodynamics in patients with septic shock: a randomized controlled trial
by: Surat Tongyoo, et al.
Published: (2025-12-01)

GRKs and Epac1 Interaction in Cardiac Remodeling and Heart Failure
by: Marion Laudette, et al.
Published: (2021-01-01)

Reduced suppressive effect of β2-adrenoceptor agonist on fibrocyte function in severe asthma
by: Chun-Yu Lo, et al.
Published: (2017-11-01)

Repurposing of the Drug Tezosentan for Cancer Therapy
by: Eduarda Ribeiro, et al.
Published: (2023-06-01)

PDE3A as a Therapeutic Target for the Modulation of Compartmentalised Cyclic Nucleotide-Dependent Signalling
by: Swaroop Ranjan Pati, et al.
Published: (2025-05-01)

Functional Significance of the Adcy10-Dependent Intracellular cAMP Compartments
by: Sofya Pozdniakova, et al.
Published: (2018-05-01)

Properties and synthesis of milrinone
by: Mirković Jelena M., et al.
Published: (2013-01-01)

Regulation of the renin-angiotensin-aldosterone system by cyclic nucleotides and phosphodiesterases
by: Stepan Gambaryan, et al.
Published: (2023-08-01)

Beta-2 adrenergic receptors increase TREG cell suppression in an OVA-induced allergic asthma mouse model when mice are moderate aerobically exercised
by: Kari J. Dugger, et al.
Published: (2018-02-01)

Nonsteroidal anti-inflammatory drugs as potential ecto-nucleotide phosphodiesterase inhibitors
by: Shumaila Tasneem, et al.
Published: (2020-03-01)

Phosphodiesterases 4B and 4D Differentially Regulate cAMP Signaling in Calcium Handling Microdomains of Mouse Hearts
by: Axel E. Kraft, et al.
Published: (2024-03-01)

The Sleep Quality- and Myopia-Linked PDE11A-Y727C Variant Impacts Neural Physiology by Reducing Catalytic Activity and Altering Subcellular Compartmentalization of the Enzyme
by: Irina Sbornova, et al.
Published: (2023-12-01)

Dysregulated Cyclic Nucleotide Metabolism in Alcohol-Associated Steatohepatitis: Implications for Novel Targeted Therapies
by: Diego Montoya-Durango, et al.
Published: (2023-10-01)

The Role of Dopamine in Repurposing Drugs for Oncology
by: Catarina Moura, et al.
Published: (2023-07-01)

Comparison of postoperative outcomes of milrinone versus dobutamine in tetralogy of Fallot with transannular patch
by: Ishan Gohil, et al.
Published: (2023-01-01)

Comparison of the Efficacy of Milrinone Injection versus Milrinone Plus Oral Sildenafil in Newborns with Pulmonary Arterial Hypertension
by: Mohammad Mehdi Bagheri, et al.
Published: (2021-01-01)

A mini-review: phosphodiesterases in charge to balance intracellular cAMP during T-cell activation
by: Marie Bielenberg, et al.
Published: (2024-03-01)

Effects of chlorogenic acid on carbachol-induced contraction of mouse urinary bladder
by: Takeharu Kaneda, et al.
Published: (2018-01-01)

Exacerbating effects of single-dose acute ethanol exposure on neuroinflammation and amelioration by GPR110 (ADGRF1) activation
by: Sharmistha Banerjee, et al.
Published: (2023-08-01)

CRISPR/Cas9 Knock-Out in Primary Neonatal and Adult Cardiomyocytes Reveals Distinct cAMP Dynamics Regulation by Various PDE2A and PDE3A Isoforms
by: Egor B. Skryabin, et al.
Published: (2023-06-01)

Linderane Suppresses Hepatic Gluconeogenesis by Inhibiting the cAMP/PKA/CREB Pathway Through Indirect Activation of PDE 3 via ERK/STAT3
by: Wei Xie, et al.
Published: (2018-05-01)

The cAMP-signaling cancers: Clinically-divergent disorders with a common central pathway
by: Graeme B. Bolger
Published: (2022-10-01)

Neurogenic Stunned Myocardium Progressing to Takotsubo Cardiomyopathy with Milrinone
by: Siddharth Srinivasan, et al.

Apicomplexan phosphodiesterases in cyclic nucleotide turnover: conservation, function, and therapeutic potential
by: William J. Moss, et al.
Published: (2024-02-01)

Hemodynamic and Clinical Outcomes of Milrinone Compared to Dobutamine in Cardiogenic Shock: A-Systematic Review and Meta-Analysis
by: William Bahagia
Published: (2023-05-01)

cAMP Compartmentalisation in Human Myometrial Cells
by: Alice Varley, et al.
Published: (2023-02-01)

Functions of PDE3 Isoforms in Cardiac Muscle
by: Matthew Movsesian, et al.
Published: (2018-02-01)

Perioperative Management of an Obstetric Patient with Eisenmenger Syndrome and Pre-Eclampsia Using Milrinone
by: C.D. Deepak Chakravarthy, et al.
Published: (2024-07-01)

A cAMP phosphodiesterase is essential for sclerotia formation and virulence in Sclerotinia sclerotiorum
by: Yan Xu, et al.
Published: (2023-05-01)

Terlipressin versus norepinephrine to prevent milrinone-induced systemic vascular hypotension in cardiac surgery patient with pulmonary hypertension
by: Mai Mohsen Abdelazziz, et al.
Published: (2019-01-01)

Assessment of inotropic and vasodilating effects of milrinone lactate in patients with dilated cardiomyopathy and severe heart failure
by: Edson Antonio Bregagnollo, et al.
Published: (1999-02-01)

Milrinone in pediatric heart failure
by: Yu. S. Aleksandrovich, et al.
Published: (2024-08-01)

A phosphodiesterase 4 (PDE4) inhibitor, amlexanox, reduces neuroinflammation and neuronal death after pilocarpine-induced seizure
by: Hyun Wook Yang, et al.
Published: (2024-07-01)

Amelioration of functional and histopathological consequences after spinal cord injury through phosphodiesterase 4D (PDE4D) inhibition
by: Melissa Schepers, et al.
Published: (2024-07-01)

Phosphodiesterases Inhibition by Bacilli Calmette-Guérin Contributes to Decrease Asthma in Allergic Rats
by: Yajuan Wang, et al.
Published: (2011-09-01)

Methylxanthines Modulate Circadian Period Length Independently of the Action of Phosphodiesterase
by: Consuelo Olivares-Yañez, et al.
Published: (2023-08-01)