Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activity

Human cytomegalovirus (HCMV) infects up to 80% of the world’s population. Here, we show that HCMV infection leads to widespread changes in human chromatin accessibility and chromatin looping, with hundreds of thousands of genomic regions affected 48 hr after infection. Integrative analyses reveal HC...

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Bibliographic Details
Published in:	eLife
Main Authors:	Khund Sayeed, Sreeja Parameswaran, Matthew J Beucler, Lee E Edsall, Andrew VonHandorf, Audrey Crowther, Omer A Donmez, Matthew R Hass, Scott Richards, Carmy R Forney, Hayley K Hesse, Sydney H Jones, Katelyn A Dunn, Jay Wright, Merrin Man Long Leong, Laura A Murray-Nerger, Vijay Yechoor, Ben E Gewurz, Kenneth M Kaufman, John B Harley, Bo Zhao, William E Miller, Leah C Kottyan, Matthew T Weirauch
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2025-09-01
Subjects:	gene regulation functional genomics virus infection cytomegalovirus epigenetics
Online Access:	https://elifesciences.org/articles/101578

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