Effectiveness and safety of lower dose prednisone for initial treatment of acute graft-versus-host disease: a randomized controlled trial

We conducted a phase III study to test the hypothesis that initial therapy with “lower dose” prednisone is effective and safe for patients with newly diagnosed acute graft-versus-host disease. We hypothesized that a 50% decrease in the initial dose of prednisone for treatment of acute graft-versus-h...

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Bibliographic Details
Published in:Haematologica
Main Authors: Marco Mielcarek, Terrence Furlong, Barry E. Storer, Margaret L. Green, George B. McDonald, Paul A. Carpenter, Mary E.D. Flowers, Rainer Storb, Michael Boeckh, Paul J. Martin
Format: Article
Language:English
Published: Ferrata Storti Foundation 2015-06-01
Online Access:https://haematologica.org/article/view/7415
Description
Summary:We conducted a phase III study to test the hypothesis that initial therapy with “lower dose” prednisone is effective and safe for patients with newly diagnosed acute graft-versus-host disease. We hypothesized that a 50% decrease in the initial dose of prednisone for treatment of acute graft-versus-host disease would suffice to control graft-versus-host disease without increasing the incidence of secondary treatment. Patients with grade IIa manifestations (upper gastrointestinal symptoms, stool volumes
ISSN:0390-6078
1592-8721

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