Effectiveness and safety of lower dose prednisone for initial treatment of acute graft-versus-host disease: a randomized controlled trial
We conducted a phase III study to test the hypothesis that initial therapy with “lower dose” prednisone is effective and safe for patients with newly diagnosed acute graft-versus-host disease. We hypothesized that a 50% decrease in the initial dose of prednisone for treatment of acute graft-versus-h...
| Published in: | Haematologica |
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| Main Authors: | , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Published: |
Ferrata Storti Foundation
2015-06-01
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| Online Access: | https://haematologica.org/article/view/7415 |
| _version_ | 1850287600777035776 |
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| author | Marco Mielcarek Terrence Furlong Barry E. Storer Margaret L. Green George B. McDonald Paul A. Carpenter Mary E.D. Flowers Rainer Storb Michael Boeckh Paul J. Martin |
| author_facet | Marco Mielcarek Terrence Furlong Barry E. Storer Margaret L. Green George B. McDonald Paul A. Carpenter Mary E.D. Flowers Rainer Storb Michael Boeckh Paul J. Martin |
| author_sort | Marco Mielcarek |
| collection | DOAJ |
| container_title | Haematologica |
| description | We conducted a phase III study to test the hypothesis that initial therapy with “lower dose” prednisone is effective and safe for patients with newly diagnosed acute graft-versus-host disease. We hypothesized that a 50% decrease in the initial dose of prednisone for treatment of acute graft-versus-host disease would suffice to control graft-versus-host disease without increasing the incidence of secondary treatment. Patients with grade IIa manifestations (upper gastrointestinal symptoms, stool volumes |
| format | Article |
| id | doaj-art-070d2cbc655c42eabf37d087f702e62d |
| institution | Directory of Open Access Journals |
| issn | 0390-6078 1592-8721 |
| language | English |
| publishDate | 2015-06-01 |
| publisher | Ferrata Storti Foundation |
| record_format | Article |
| spelling | doaj-art-070d2cbc655c42eabf37d087f702e62d2025-08-19T23:36:51ZengFerrata Storti FoundationHaematologica0390-60781592-87212015-06-01100610.3324/haematol.2014.118471Effectiveness and safety of lower dose prednisone for initial treatment of acute graft-versus-host disease: a randomized controlled trialMarco Mielcarek0Terrence Furlong1Barry E. Storer2Margaret L. Green3George B. McDonald4Paul A. Carpenter5Mary E.D. Flowers6Rainer Storb7Michael Boeckh8Paul J. Martin9Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA;University of Washington, Seattle, WA, USAClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USAClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA;University of Washington, Seattle, WA, USAUniversity of Washington, Seattle, WA, USA;Vaccines and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USAClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA;University of Washington, Seattle, WA, USAClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA;University of Washington, Seattle, WA, USAClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA;University of Washington, Seattle, WA, USAClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA;University of Washington, Seattle, WA, USAUniversity of Washington, Seattle, WA, USA;Vaccines and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USAClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA;University of Washington, Seattle, WA, USAWe conducted a phase III study to test the hypothesis that initial therapy with “lower dose” prednisone is effective and safe for patients with newly diagnosed acute graft-versus-host disease. We hypothesized that a 50% decrease in the initial dose of prednisone for treatment of acute graft-versus-host disease would suffice to control graft-versus-host disease without increasing the incidence of secondary treatment. Patients with grade IIa manifestations (upper gastrointestinal symptoms, stool volumes https://haematologica.org/article/view/7415 |
| spellingShingle | Marco Mielcarek Terrence Furlong Barry E. Storer Margaret L. Green George B. McDonald Paul A. Carpenter Mary E.D. Flowers Rainer Storb Michael Boeckh Paul J. Martin Effectiveness and safety of lower dose prednisone for initial treatment of acute graft-versus-host disease: a randomized controlled trial |
| title | Effectiveness and safety of lower dose prednisone for initial treatment of acute graft-versus-host disease: a randomized controlled trial |
| title_full | Effectiveness and safety of lower dose prednisone for initial treatment of acute graft-versus-host disease: a randomized controlled trial |
| title_fullStr | Effectiveness and safety of lower dose prednisone for initial treatment of acute graft-versus-host disease: a randomized controlled trial |
| title_full_unstemmed | Effectiveness and safety of lower dose prednisone for initial treatment of acute graft-versus-host disease: a randomized controlled trial |
| title_short | Effectiveness and safety of lower dose prednisone for initial treatment of acute graft-versus-host disease: a randomized controlled trial |
| title_sort | effectiveness and safety of lower dose prednisone for initial treatment of acute graft versus host disease a randomized controlled trial |
| url | https://haematologica.org/article/view/7415 |
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